Pharmaciana Vol.10, No.3, Nov 2020, Page. 343-352 ISSN: 2088 4559; e-ISSN: 2477 0256 DOI: 10.12928/pharmaciana.v10i3.16406 343 Journal homepage: http://journal.uad.ac.id/index.php/PHARMACIANA Potentials of rose (Rosa damascena) petals and receptacles extract as antioxidant and antihyaluronidase Desi Yustra Sari Dewi 1 , Chrismis Novalinda Ginting *1 , Linda Chiuman 1 , Ermi Girsang 1 , Rr. Anisa Siwianti Handayani 2 , Wahyu Widowati 3 1 Faculty of Medicine, Universitas Prima Indonesia Jl. Belanga No. 1 Simp. Ayahanda, Medan 20118, North Sumatera, Indonesia 2 Aretha Medika Utama, Biomolecular and Biomedical Research Center Jl. Babakan Jeruk II No. 9, Bandung 40163, West Java, Indonesia 3 Medical Research Center, Faculty of Medicine, Maranatha Christian University Jl. Prof. Drg. Surya Sumantri No. 65, Bandung 40164, West Java, Indonesia Submitted: 16-04-2020 Reviewed: 02-07-2020 Accepted: 12-10-2020 ABSTRACT Free radicals affect aging by unspecific lead breakdown to macromolecules, like DNA, lipids, and proteins. The degradation of the extracellular matrix affects skin aging and correlated with the hyaluronidase enzyme. Rose (Rosa damascena) petal extract and rose receptacle extract can scavenge free radicals, thus hindering the aging process. This study examined phenolic and flavonoid content, the antioxidant, anti-hyaluronidase potential from rose petal extract (RPE) and rose receptacle extract (RRE) inhibiting skin aging. In this study, hydrogen peroxide (H 2 O 2 ) scavenging activity assay was done to analyze the antioxidant activity. Futhermore, the hyaluronidase inhibitory assay was done to analyse the antiaging activity. The characteristic of RPE and RRE were measured the phenolics and flavonoids content. The phenolics content of RPE and RRE were 9.66 μg GAE/mg RPE and 4.31 μg GAE/mg RRE, respectively, while the flavonoids content of RPE and RRE were 1.22 μg QE/mg RPE and 0.59 μg QE/mg RRE, respectively. The median inhibitory (IC 50 ) of H 2 O 2 scavenging of RPE (207.99 μg/mL) was more active than RRE (348.24 μg/mL). RPE's anti-hyaluronidase (IC 50 : 51.68 μg/mL) was as effective as RRE (IC 50 : 51.98 μg/mL). Antioxidant and antiaging activities from RPE and RRE are promising natural agents for aging therapy. Keywords: Antioxidant, antiaging, hyaluronidase, Rosa damascena *Corresponding author: Chrismis Novalinda Ginting Faculty of Medicine, Universitas Prima Indonesia Jl. Belanga No. 1 Simp. Ayahanda, Medan 20118, North Sumatera, Indonesia Email: chrismis@unprimdn.ac.id