Research Article Soluble and Endogenous Secretory Receptors for Advanced Glycation End Products in Threatened Preterm Labor and Preterm Premature Rupture of Fetal Membranes RafaB Rzepka, 1 Barbara DoBegowska, 2 Aleksandra Rajewska, 1 Sebastian Kwiatkowski, 1 Daria SaBata, 2 Marta Budkowska, 2 Leszek DomaNski, 3 Wioletta MikoBajek-Bedner, 1 and Andrzej Torbé 1 1 Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-204 Szczecin, Poland 2 Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, 70-204 Szczecin, Poland 3 Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-204 Szczecin, Poland Correspondence should be addressed to Rafał Rzepka; rafalrz123@gmail.com Received 6 February 2015; Accepted 19 March 2015 Academic Editor: Igor Hudic Copyright © 2015 Rafał Rzepka et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Te aim of the study was to compare sRAGE and esRAGE plasma levels in pregnant women with (A) threatened premature labor ( = 41), (B) preterm premature rupture of membranes ( = 49), and (C) preterm rupture of membranes at term ( = 48). Te relationship between these and classic intrauterine infection markers and the latent time from symptoms up to delivery depending on RAGE’s concentration were investigated. In groups A and B, a positive correlation was found between plasma sRAGE and latent time ( = 0,422;  = 0,001;  = 0,413,  = 0,004, resp.). High prognostic values were found in both groups for plasma sRAGE concentration and the latent time from symptoms up to delivery. Groups B and C presented higher levels of esRAGE than group A (526,315 ± 129,453 pg/mL and 576,212 ± 136,237 pg/mL versus 485,918 ± 133,127 pg/mL, < 0,05). Te conclusion is that sRAGE concentration can be a favorable prognostic factor in the presence of symptoms of threatened premature labor. Higher esRAGE plasma level in case of the rupture of membranes in mature and premature pregnancy suggests its participation in fetal membranes destruction. 1. Introduction Preterm labor is defned as a birth of a newborn that occurs between 22nd and 37th week of gestation. Some 30–35% of all premature labors are iatrogenic, due to maternal or fetal indications, while the other 40–65% complete sponta- neously in the consequence of preterm uterine contractility or membrane rupture [1]. Preterm end of pregnancy is the most common cause of morbidity and mortality of the newborns as well in the United States as in Europe [1, 2]. Despite the signifcant development of perinatal medicine in recent years, the prevalence of premature birth has not decreased and it still remains 10–20%. Many factors have been hypothesized as pathogenic for premature labor, but the activation of maternofetal infammatory response, leading to uterine activity or preterm premature rupture of membranes (pPROM), is believed to be the most corresponding to contemporary knowledge [3]. Most of investigators consider preterm labor as an acute obstetric disease related to ascending bacterial infection of lower pole of membranes with exogenic or endogenic microbes, with subsequent rapid maternal and fetal immuno- logic response [4–7]. In women diagnosed with chorioam- nionitis and premature labor increased plasma levels of some pathogen-associated molecular patterns (PAMPs), such as interleukin-1 beta (IL-1), calcium binding protein A5 (S100A5), prolyl 4-hydroxylase alpha polypeptide 2 (P4HA2), interleukin-6 (IL-6), interleukin-8 (IL-8), lipopolysaccha- rides (LPS), tumor necrosis factor-alpha (TNF-), and C- reactive protein (CRP), were discovered [8–11]. Yet, in some Hindawi Publishing Corporation BioMed Research International Volume 2015, Article ID 568042, 10 pages http://dx.doi.org/10.1155/2015/568042