Bioactive Carbohydrates and Dietary Fibre 24 (2020) 100237 Available online 30 August 2020 2212-6198/© 2020 Elsevier Ltd. All rights reserved. Evaluation of the pancreatoprotective effect of algal extracts on Alloxan-induced diabetic rat Eman A. Alwaleed a, * , Asmaa Jillany a , Naglaa R.A. Kasem b , Hamdy Galal a a Department of Botany, Faculty of Science, South Valley University, Qena, Egypt b Department of Zoology, Faculty of Science, South Valley University, Qena, Egypt A R T I C L E INFO Keywords: Halimeda opuntia Polycladia myrica Diabetes Kidney function ABSTRACT Purpose: Diabetes is a metabolic syndrome which is associated with the worldwide major public health problems. In the present research, with respect to the traditional and ethnic uses of Polycladia myrica and Halimeda opuntia algal extract for healing of diabetic diseases. Materials and methods: algal extracts at 100 and 200 mg/kg was administered orally to Alloxan-induced diabetic rats once daily for 15 days. Serum glucose levels, Complete Blood Count (CBC) and Kidney function of rats were measured at the end of experimental. The liver function of the pancreas was also observed. Results: The preprandial and postprandial glucose levels in the group treated with algal extracts (100 and 200 mg/kg) were signifcantly reduced compared with those of the diabetes group. Additionally, the levels of CBC, kidney function and liver function in the 100 and 200 mg/kg algal extract were signifcantly different from those in the diabetes group. Conclusion: The results illustrated that, algal extracts at 100 & 200 mg/kg had the best capability to lower the levels of glucose and we can conclude that Halimeda extract is the best effective extract as preventive medication (pre-treatment) and the polycladia extract with concentration 100 is the best effective extract as medication (post-treatment). 1. Introduction Algae take considerable position among living organisms because of their features that make them categorized as a potent and hopeful sys- tem as a natural resource. They are signifcant in various applications as antimicrobial, anti-viral, anti-oxidants, anticancer, anti-diabetic and anti-infammatory (Yu, Shen, Song, & Xie, 2018). Marine algae have essential actions for diabetes prevention and administration due to the healthy nutritional structure that may support diabetics such as, un- saturated fatty acids, dietary fbers in addition to bioactive composition (Sharifuddin, Chin, Lim, & Phang, 2015). Diabetes mellitus (DM) is one of the great congregations and chronic defects of carbohydrate, lipid and protein metabolism described by continue rise of blood glucose levels. This cans either product from a fractional or complex stopping of insulin excretion or making, or resis- tance to insulin work (Longe, Momoh, & Adepoju, 2015). Survey on anti-diabetic potential of marine algae is generally nonhomogeneous as certain seaweed components, bioactive compounds and mechanisms of action have been tested relatively more wide than others. Apart from unsaturated fatty acids and dietary fbers, studies on anti-diabetic features involving polyphenols from seaweed are consid- erably more common with a diversity of polyphenolic components iso- lated versus many well-known anti-diabetic targets. Polyphenolic components are famous for making complexes upon interaction with different proteins (Sharifuddin et al., 2015). And those extracted from vegetables and fruits display several activities comprising anti-diabetes (Anhˆ e et al., 2013). The anti-diabetic targets of marine algae bioactive compounds comprising repression of enzymes involved in maintenance of glucose homeostasis like α-amylase, α-glucosidase, aldose reductase and protein tyrosine phosphatase 1B (PTP1B), suppression of incretin hormones activities, stimulating of glucose uptake by cells, anti-obesity, anti-infammation as well as cytoprotection of β-cells (Sharifuddin et al., 2015). * Corresponding author. E-mail address: Eme_biologist@sci.svu.edu.eg (E.A. Alwaleed). Contents lists available at ScienceDirect Bioactive Carbohydrates and Dietary Fibre journal homepage: http://www.elsevier.com/locate/bcdf https://doi.org/10.1016/j.bcdf.2020.100237 Received 6 January 2020; Received in revised form 10 July 2020; Accepted 6 August 2020