Review Article Current Trends on Solid Dispersions: Past, Present, and Future Ruba Malkawi , 1 Walla I. Malkawi, 2 Yahia Al-Mahmoud, 1 and Jawad Tawalbeh 3 1 School of Pharmacy, Jadara University, P.O. Box 733, Irbid 21110, Jordan 2 School of Pharmacy, Iowa State University, Ames, IA 50011, USA 3 School of Business, Teesside University, Campus Heart, Southfield Rd, Middlesbrough TS1 3BX, UK Correspondence should be addressed to Ruba Malkawi; r.malkawi@jadara.edu.jo Received 12 July 2022; Revised 10 August 2022; Accepted 21 September 2022; Published 22 October 2022 Academic Editor: Srinivas Mutalik Copyright © 2022 Ruba Malkawi et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Solid dispersions have achieved significant interest as an effective means of enhancing the dissolution rate and thus the bio- availability of a range of weakly water-soluble drugs. Solid dispersions of weakly water-soluble drugs with water-soluble carriers have lowered the frequency of these problems and improved dissolution. Solid dispersion is a solubilization technology em- phasizing mainly on, drug-polymer two-component systems in which drug dispersion and its stabilization is the key to for- mulation development. erefore, this technology is recognized as an exceptionally useful means of improving the dissolution properties of poorly water-soluble drugs and in the latest years, a big deal of understanding has been accumulated about solid dispersion, however, their commercial application is limited. In this review article, emphasis is placed on solubility, BCS classification, and carriers. Moreover, this article presents the diverse preparation techniques for solid dispersion and gathers some of the recent technological transfers. e different types of solid dispersions based on the carrier used and molecular arrangement were underlined. Additionally, it summarizes the mechanisms, the methods of preparing solid dispersions, and the marketed drugs that are available using solid dispersion approaches. 1. Introduction e oral route is the most convenience route for drug adminstration and favore mode of delivery [1]. From the patient’s standpoint, swallowing and medication is a com- fortable and familiar method of taking medication. As a result, orally delivered drugs are often more effective than alternative modes of administration, such as parenteral, in terms of patient compliance and drug treatment. When an active substance is given orally, it must first dissolve in the stomach and/or intestinal fluids before it can pass through the GI tract’s membranes and reach systemic circulation [2]. erefore, water solubility and/or membrane permeability of the drug molecule are significant contributors to drug ab- sorption from the gastrointestinal (GI) tract, which causes low medication bioavailability of the medications. Consequently, a drug with weak aqueous solubility usually shows a disso- lution rate of limited absorption, while a drug with weak membrane permeability usually shows a permeation rate of limited absorption [3]. Pharmaceutical scientists have two approaches to im- proving the oral bioavailability of pharmacologically active agents: (i) improving the solubility and dissolution rate of poorly water-soluble medications, and (ii) improving the permeability of poorly permeable drugs [4]. In the pharmaceutical literature, a variety of strategies have been used to improve the dissolving capabilities of weakly water-soluble medications other than solid dispersions. Some of these strategies are salt creation, complexation with cyclo- dextrins, solubilization of pharmaceuticals in solvent(s), and particle size reduction; however, each of these procedures has significant limitations, such as poor yield, expensive, time consuming, and very low drug solubility [5]. On the other hand, formulating pharmaceuticals as solid dispersions pro- vides several processing and excipient alternatives, allowing for greater flexibility for formulating oral delivery systems of poorly tolerated water-soluble medications [6]. Much of the research that has been published on solid dispersion technologies includes medications that are poorly water-soluble and highly permeable to biological membranes Hindawi Advances in Pharmacological and Pharmaceutical Sciences Volume 2022, Article ID 5916013, 17 pages https://doi.org/10.1155/2022/5916013