1S Supporting Information for: Programmable Peptide-Crosslinked Nucleic Acid Nanocapsules as a Modular Platform for Enzyme Specific Cargo Release Joshua J. Santiana † , Binglin Sui † , Nicole Gomez and Jessica L. Rouge* Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA *Corresponding author: jessica.rouge@uconn.edu Table of Contents General Method (I) ................................................................................................................... 2S Representative Schemes (II) .................................................................................................... 2S Crosslinkers (III) .................................................................................................................. 2S-3S Nanoparticle Syntheses (IV)................................................................................................ 3S-4S Characterization (V) ............................................................................................................ 4S-8S Electron Microscopy of NANs in HeLa Cells (VI) ............................................................... 9S-10S Cell Viability (VII)............................................................................................................. 10S-11S Confocal Microscopy (VIII) .............................................................................................. 12S-13S Cathepsin B Cleavage Activity (IX)......................................................................................... 13S MMP9-NAN Specificity (X) .............................................................................................. 14S-15S Raw Fluorescence Data (XI) ........................................................................................... 15S-17S References (XII) ..................................................................................................................... 17S