Accepted Manuscript Discovery of Pyrazolo[1,5-a]pyrimidine-based Pim Inhibitors: A Template- Based Approach Michael P. Dwyer, Kartik Keertikar, Kamil Paruch, Carmen Alvarez, Marc Labroli, Cory Poker, Thierry O. Fischmann, Rosemary Mayer-Ezell, Richard Bond, Yan Wang, Rita Azevedo, Timothy J. Guzi PII: S0960-894X(13)01059-7 DOI: http://dx.doi.org/10.1016/j.bmcl.2013.08.110 Reference: BMCL 20848 To appear in: Bioorganic & Medicinal Chemistry Letters Received Date: 10 June 2013 Revised Date: 26 August 2013 Accepted Date: 29 August 2013 Please cite this article as: Dwyer, M.P., Keertikar, K., Paruch, K., Alvarez, C., Labroli, M., Poker, C., Fischmann, T.O., Mayer-Ezell, R., Bond, R., Wang, Y., Azevedo, R., Guzi, T.J., Discovery of Pyrazolo[1,5-a]pyrimidine-based Pim Inhibitors: A Template-Based Approach, Bioorganic & Medicinal Chemistry Letters (2013), doi: http:// dx.doi.org/10.1016/j.bmcl.2013.08.110 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.