IP International Journal of Ocular Oncology and Oculoplasty 2023;9(1):30–36 Content available at: https://www.ipinnovative.com/open-access-journals IP International Journal of Ocular Oncology and Oculoplasty Journal homepage: https://ijooo.org/ Original Research Article Periocular and orbital amyloidosis: A case series study Syeed Mehbub Ul Kadir 1, *, Golam Haider 2 , Mukti Rani Mitra 3 , Rajendra Prakash Maurya 4 , Nishat Parveen 5 , Tanjila Hossain 6 , Riffat Rashid 7 , Md. Ismail Hossain 5 , Narayon Chandra Bhowmik 8 , Sadia Sultana 7 1 Sheikh Fazilatunnesa Mujib Eye Hospital & Training Institute, Gopalganj, Bangladesh, India 2 Bangladesh Eye Hospital & Institute, Dhaka, Bangladesh 3 Dhaka Medical College and Hospital, Dhaka, Bangladesh 4 Regional Institute of Ophthalmology, IMS, Banaras Hindu University, Varanasi, Uttar Pradesh, India 5 National Institute of Ophthalmology & Hospital, Dhaka, Bangladesh 6 Sir Sallimullah Medical College, Dhaka, Bangladesh 7 Ispahai Islamia Eye Institute & Hospital, Farmgate, Dhaka, Bangladesh 8 BIRDEM General Hospital, Dhaka, Bangladesh ARTICLE INFO Article history: Received 15-02-2023 Accepted 19-03-2023 Available online 26-05-2023 Keywords: Amyloidosis Eyelid Conjunctiva Orbit Histopathology ABSTRACT Purpose: To present the demographic and clinical profile and management strategies of patients with periocular and orbital amyloidosis. Materials and Methods : This study retrospectively reviewed the clinical records of twelve patients with periocular and orbital amyloidosis between January 2011 and February 2019 in Bangladesh. Clinical evaluation and Imaging studies were helpful to diagnosis the patients, but surgical biopsy followed by histopathological study was done to confirm the diagnosis. All cases were investigated to rule out systemic amyloidosis with limited facility and no systemic involvement was found. Informed written consent for surgical procedure and Clinical photographs were taken for all patients for documentation and clinical research. Results: The study included thirteen patients including nine male (69.2%) and four female (30.8%) patients. Among the patients, seven (53.8%) were unilateral and six (46.2%) were bilateral. Clinical signs and symptoms were visible or palpable periocular mass or tissue infiltration in all 13 (100%) cases, mechanical ptosis was observed in 6 (46.2%) cases, and proptosis or globe displacement was found in 4 (30.8%). Age ranges from 25 years to 65 years. The Mean age ± SD was 48.23 ± 10.64 years. Treatment modalities were mainly open surgical biopsy either excision (53.8%) or debulking (46.2%). Conclusions: Periocular and orbital amyloidosis may present with a wide spectrum of clinical findings depending on the location of the disease. The goal of treatment is to preserve function and to prevent sight-threatening complications. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact: reprint@ipinnovative.com 1. Introduction Amyloidosis is a progressive, diverse, heterogenous disorders involving the deposition of hyaline extracellular * Corresponding author. E-mail address: mehbubkadir@gmail.com (S. M. U. Kadir). abnormally folded proteins in the various tissues throughout the body including the orbit and periocular tissues which ultimately causes tissue destruction. 1–3 The clinical presentation classified by the clinicopathological features, the disease locations and magnitude of amyloid deposits. 4 Localized amyloidosis involves only one organ, but https://doi.org/10.18231/j.ijooo.2023.006 2581-5024/© 2023 Innovative Publication, All rights reserved. 30