Influence of Selected Natural Polymers on In-vitro Release of Colon Targeted Mebeverine HCl Matrix Tablet Dharmarajsinh Chauhan *, Axay Patel, Shrenik Shah Department of Pharmaceutics, MJRP College of Health Care & Allied Science, Jaipur, Affiliated to Mahatma Jyoti Rao Phoole University Key words: Irritable bowel syndrome; Mebeverine Hcl; Colon specific; Polysaccharides; In- vitro release; How to Cite this Paper: Dharmarajsinh Chauhan*, Axay Patel, Shrenik Shah “Influence of Selected Natural Polymers on In-vitro Release of Colon Targeted Mebeverine HCl Matrix Tablet”, Int. J. Drug Dev. & Res., April-June 2012, 4(2): 247-255 Copyright © 2012 IJDDR, Dharmarajsinh Chauhan et al. This is an open access paper distributed under the copyright agreement with Serials Publication, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. INTRODUCTION Irritable bowel syndrome (IBS) is a disorder characterized most commonly by cramping, abdominal pain, bloating, constipation and diarrhea. It occurs more often in women that in men, and it begins before the age of 35 in about 50 percent of International Journal of Drug Development & Research | April-June 2012 | Vol. 4 | Issue 2 | ISSN 0975-9344 | Available online http://www.ijddr.in Covered in Official Product of Elsevier, The Netherlands SJR Impact Value 0.03 & H index 2 ©2012 IJDDR Abstract The objective of the present study was to develop and evaluate colon specific matrices of mebeverine HCl using various polysaccharides like guar gum, Locust bean gum and xanthan gum by direct compression method. The matrix tablets were evaluated for their physico-chemical properties, swelling study, in-vitro release study and stability studies. The prepared tablets were found to be uniform with respect to thickness (5.53 to 6.03 mm) and hardness (5.7 to 6.9 kg/cm 2 ). The friability (0.41 to 0.95 %) and weight variation (1.04-1.66%) of different batch of tablets were found within prescribed limits. Drug content (96.01 to 99.89 %) was found uniform within the batches of different tablets. Swelling studies indicated that, matrix tablets prepared with XG (X4) swelled more as compared to those prepared using GG and LBG. Release profiles indicated that, increase in the polymer concentration has drastically retarded the release of Mebeverine Hcl. The optimized tablets prepared using GG (G4), LG (L4) & XG (X4) showed controlled release over periods of 24 hrs, whereas the marketed product controlled the drug release over a period of 12 hrs. The mechanism of drug release was Non-Fickian diffusion controlled first order kinetics for optimized matrix tablets of GG (G4) and LBG (L4) where as for XG (X4) it followed Highuchi model. The developed matrix tablets can be viewed as a better approach in the colonic delivery of Mebeverine HCl. *Corresponding author, Mailing address: Mr. Dharmarajsinh Chauhan Email: dharmraj_chauhan@yahoo.com Article History:------------------------ Date of Submission: 17-04-2012 Date of Acceptance: 30-04-2012 Conflict of Interest: NIL Source of Support: NONE FULL Length Research Paper Covered in Index Copernicus with IC Value 4.68 for 2010 Int. J. Drug Dev. & Res., April-June 2012, 4 (2): 247-255 Covered in Scopus & Embase, Elsevier 247