www.proteomics-journal.com Page 1 Proteomics Received: NOVEMBER 12, 2018; Revised: MARCH 27, 2019; Accepted: MAY 07, 2019 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/pmic.201800394. This article is protected by copyright. All rights reserved. The Proteome of Pancreatic Cancer-Derived Exosomes Reveals Signatures Rich in Key Signaling Pathways Song Han 1* , Zhiguang Huo 2* , Kathy Nguyen 1 , Fanchao Zhu 3 , Patrick W Underwood 1 , Kari B Green Basso 4 , Thomas J. George 5 , Steven J. Hughes 1 1 Department of Surgery, 2 Department of Biostatistics, 3 Interdisciplinary Center for Biotechnology Research Proteomic & Mass Spectrometry Core, 4 Department of Chemistry, 5 Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610. *Corresponding Authors: Song Han, Department of Surgery, University of Florida College of Medicine. 1600 SW Archer Rd, Gainesville, FL 32610. Phone: 352-273-7758, Fax: 352-265-1060, E-mail: song.han@surgery.ufl.edu Zhiguang Huo, Department of Biostatistics, University of Florida College of Medicine. 1600 SW Archer Rd, Gainesville, FL 32610. Phone: 352-294-5929, Fax: 352294-5931, E-mail: zhuo@ufl.edu Number of tables and figures: 2 tables and 8 figures Supplementary information: 2 supplementary word documents, 5 supplementary tables and 4 supplementary figures