1 Polyphenol-rich Muscadine Grape Extract Reduces Triple Negative Breast Cancer Metastasis in Mice with Changes in the Gut Microbiome Marianne Collard a , Nataleigh N Austin a , Heather Brown-Harding b , Brian Westwood a , E. Ann Tallant a , Patricia E. Gallagher a a Hypertension & Vascular Research, Wake Forest School of Medicine, Winston-Salem, NC, 27101, US b Department of Biology, Wake Forest University, 455 Vine Street, Winston-Salem, NC, 27101, US Corresponding Author: Patricia E. Gallagher; Hypertension & Vascular Research, Wake Forest School of Medicine, Winston-Salem, NC, 27101, US; Tel: +1 336-716-4455; Email: pgallagh@wakehealth.edu Author ORCIDs: Marianne Collard: 0000-0001-5267-8794 Heather Brown-Harding: 0000-0001-9636-2345 E. Ann Tallant: 0000-0003-4162-4373 Patricia E. Gallagher: 0000-0003-1834-4189