S1 A Convenient One-Pot Synthesis of 1,8- Naphthyridones Shawn A. Springfield,* Karen Marcantonio, Scott Ceglia, Jennifer Albaneze-Walker, Peter G. Dormer, Todd D. Nelson and Jerry A. Murry shawn_springfield@merck.com Table of Contents I. Supporting Information…………………………………………………… S1 II. General Procedure for the preparation of 1,8 - Naphthyridones ……... S2 III. 1 H and 13 C data for new compounds ……………………………….. S2 – S4 Supporting Information. Reactions were carried out under an atmosphere of dry nitrogen. Reagents and solvents were used as received from commercial sources. Acetonitrile contained <100 g/mL water as determined by Karl-Fischer titration. All reactions were monitored by HPLC analysis using Phenomenex (Luna 5u Phenyl – Hexyl) 4.60 x 250 mm column, eluent: CH 3 CN / 0.1% H 3 PO 4 buffer. Initial conditions 40% CH 3 CN with a gradient to 80% CH 3 CN over 15 min. Flow rate: 1ml/min, UV detection at 220nm.