A new standardized phytoextract from red orange and lemon wastes (Red orange and Lemon Extract) reduces basophil degranulation and activation. Supplementary Material Massimo Caruso a, b* , Simona Fabroni c , Rosalia Emma a , Gabriele Ballistreri c , Margherita Amenta c , Walter Currenti a , Calogero Rinzivillo d and Paolo Rapisarda c a Department of Biomedical Sciences and Biotechnology (BIOMETEC) – University of Catania, Via S. Sofia 97, 95123, Catania, Italy b Department of Clinical and Experimental Medicine (MEDCLIN) – University of Catania, Via S. Sofia 78, 95123, Catania, Italy c Council for Agricultural Research and Economics (CREA) - Research Centre for Olive, Citrus and Tree Fruit, Corso Savoia 190, 95024, Acireale, Italy d Clinical Nutrition & Integrated Supportive Therapy-Department of Medical-Surgical Sciences & Advanced Technology – Hospital University “Policlinico-Vittorio Emanuele” – Catania * Corresponding author Massimo Caruso Department of Biomedical Sciences and Biotechnology (BIOMETEC) – University of Catania, Via S. Sofia 97, 95123, Catania, Italy mascaru@unict.it