Vibha Sushilendu et al JMSCR Volume 07 Issue 02 February 2019 Page 211 JMSCR Vol||07||Issue||02||Page 211-215||February 2019 Study of Lipid profile in pulmonary TB cases: pre and post anti-tuberculosis treatment Authors Dr Vibha Sushilendu 1 , Dr Narendra Kumar 2 , Dr Uday Kumar 3 1 SR, Biochemistry Dept., IGIMS 2 SR, Dept. of Gen. Medicine, NMCH 3 Prof. and HOD, Biochemistry Dept, IGIMS Abstract Tuberculosis is a major public health problem where India accounts for one fifth of the global burden of TB incident cases. Changes in blood lipid profile has been observed during the natural course of TB infection. Decrease in the level of both TC and HDL cholesterol has been observed in the early stages. This study was undertaken to study the lipid profile of newly diagnosed pulmonary TB patients, to compare it with healthy control and to subsequently study the effect of ATT on lipid profile. 50 newly diagnosed pulmonary TB patients and 50 age and sex matched healthy controls were selected for this study. All the lipid parameters were found to be significantly low in the pulmonary TB infected cases compared to control, at the time of diagnosis. After the completion of ATT, all the lipid parameters were found to increase from the initial value. Recovery from TB after successful ATT is accompanied by improvement of lipid parameters. Keywords: pulmonary TB, ATT, lipid profile. Introduction Tuberculosis (TB) caused by the tubercle bacillus, Mycobacterium tuberculosis (MTB), is a potentially fatal, contagious disease which still remains a major global health care issue [1] . It is mainly a lung disease where it forms localized infection after inhalation. TB can however affect any part of the body. Almost one third of the world’s population is infected with Mycobacterium tuberculosis with the majority of these individuals living in less developed countries (WHO, Global Tuberculosis Control, 2011). Worldwide, TB is responsible for more than 1.5 million deaths every year. India is a nation ,which is both endemic and epidemic to tuberculosis. Tuberculosis is a major public health problem where India accounts for one fifth of the global burden of TB incident cases. Almost 40 percent of the population in India is infected with the TB bacilli. It is the 2nd leading cause of death killing 2 million people each year [2-5] . Cholesterol, mainly because of its involvement in cardiovascular diseases, has received much attention in recent years. Current recommenda- tions for treatment are aimed at reducing the serum cholesterol levels. However, there are increasing evidences that indicate a link between low blood cholesterol levels and a number of human diseases including tuberculosis. It is reported that low total cholesterol level promotes www.jmscr.igmpublication.org Index Copernicus Value: 79.54 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v7i2.40