May-June 2022 Indian Journal of Pharmaceutical Sciences Review Article 519 Phytochemicals: A Novel Approach for the Management of Coronavirus Disease 2019 R. S. SHIVATARE*, R. MUSALE, N. K. BHUTALE, S. M. KEWATKAR 1 , H. L. TARE 2 , VIBHAVARI CHATUR 3 , A. N. KHATAWAKAR 4 AND D. S. SURYAVANSHI 5 Department of Pharmacy, Jagdishprasad Jhabarwal Tibervala University, Jhunjhunu, Rajasthan 333001, 1 Department of Pharmacognosy, Rajarshi Shahu College of Pharmacy, Buldana, Maharashtra 443001, 2 Department of Pharmacy, Sharadchandra Pawar College of Pharmacy, Otur, Maharashtra 412409, 3 Department of Pharmaceutics, Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Pune, Maharashtra 411019, 4 Department of Pharmacy, Anuradha College of Pharmacy, Chikhli, Maharashtra 443201, 5 Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Pune, Maharashtra 411044, India Shivatare et al.: Phytochemicals in the Management of Coronavirus Disease 2019 The severe acute respiratory syndrome coronavirus 2, formerly known as 2019 novel coronavirus, the causative pathogen of coronavirus disease 2019 is a major source of disaster in the 21 st century. In the second meeting of the Emergency Committee, the World Health Organization declared that coronavirus disease 2019 is a “public-health emergency of international concern” on 30 January, 2020. Coronavirus is transmitted via airborne droplets from human to human or human to animal. Through membrane angiotensin-converting enzyme 2 exopeptidase receptor coronavirus enters in human cell. For the treatment of this sudden and lethal disease during coronavirus disease 2019, there are no specifc anti-virus drugs or vaccines. Still, the development of these medicines will take months, even years. Currently there is need of supportive care and non-specifc treatment to improve the symptoms of coronavirus disease 2019 infected patient. For this specifc indication, rapid performance of herbal medicine or phytochemicals can contribute as an alternative measure. Phytochemicals are a powerful group of chemicals that are derived from plants origin hence causing fewer side efects because of less use of additives, preservatives or excipients. Hence, this review will focus on some phytochemicals which may control and prevent severe acute respiratory syndrome coronavirus 2. Further, the existing healing options, drugs accessible, ongoing trials and current diagnostics to treat severe acute respiratory syndrome coronavirus 2 have been discussed. We suggested phytochemicals extracted from herbal plants are potential novel therapeutic approaches, completely targeting severe acute respiratory syndrome coronavirus 2 and its pathways. Key words: Severe acute respiratory syndrome coronavirus 2, phytochemicals, herbal medicine, coronavirus disease 2019 Coronaviruses (CoVs) classifed to the subfamily Orthocoronavirinae in the family Coronaviridae and order Nidovirales. The subfamilies Orthocoronavirinae again contain four genera, namely Alphacoronavirus (α-CoV), Betacoronavirus (β-CoV), Gammacoronavirus (γ-CoV) and Deltacoronavirus (δ-CoV). From that, α and β-CoV genera are known to infect mammals, whilst δ and γ-CoVs are identifed to infect birds. Coronavirus Disease 2019 (COVID-19) is not the frst severe respiratory infection epidemic originated by the corona virus. In the past few decades, CoVs have caused three outbreak infections, namely, COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) [1,2] . This article gives a bird’s eye view about this new virus i.e. COVID-19 and phytochemicals which may be efective in the treatment of COVID-19 as given in fg. 1. In view of the fact that awareness about this new virus is speedily developing, readers are urged to modernize themselves repeatedly. HISTORY Novel Coronavirus (nCoV)-precipitated pneumonia, which was named by the World Health Organization (WHO) on the February 11, 2020 as COVID-19, has swiftly accelerated in epidemic scale since it frst appeared during December 2019, inside Wuhan city, China. The international virus classifcation commission, on the same day, declared that the nCoV was named as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Right now, the *Address for correspondence E-mail: rakeshshivatarerp@gmail.com Accepted 02 May 2022 Revised 20 August 2021 Received 01 June 2020 Indian J Pharm Sci 2022;84(3):519-531 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms