54 Pak J Med Sci 2010 Vol. 26 No. 1 www.pjms.com.pk Original Article SHORT TERM RESULTS OF CONCOMITANT INTRANASAL ADMINISTRATION OF SALMON CALCITONIN IN INTERTROCHANTERIC FEMUR FRACTURES OPERATED UPON USING DYNAMIC HIP SCREW Nasser Sarraf an 1 , Seyed Abdolhossein Mehdinasab 2 , Ahmad Dasht bozorg 3 , Mohammad Reza Pipelzadeh 4 , Hooman Pedram 5 ABSTRACT Objectives: To evaluate the effect of nasal calcitonin spray in union of the intertrochanteric fractures of elderly e female patients. Met hodology: Fifty female patients aged above 60 years (mean age = 73.9 years) old with Intertrochanteric fracture were operated from Sept 2005 to August 2006 by dynamic hip screw. In a randomized controlled trial, patients were divided into two groups A and B. Each group had 25 patients. After hospitalization 200 IU of salmon calcitonin as a single dose nasal spray was administered to patients of group A, daily for 3 months and a placebo spray was used in patients of group B. serum level of alkaline phosphatase and time of appearance of a bone callus in a plain radiograph were compared in the two groups twice weekly for 8 weeks. Result s: About 72%of patients in group A showed signs of union as the appearing of bone callus in radiograph in the 3rd week, compared to 40% in group B. Twenty of patients in group A (80 %) and 20% of the group B had an increase in serum alkaline phosphatase from the 15th day after injury (P<0.005). Meanwhile alkaline phosphatase levels in group A was 185 IU on 15 the day compared to 140 IU on group B. and values were 443 IU and 210 IU on 90th day respectively. As regards the time of appearance of the union signs in a plain bone radiograph, 72%of patients in group A have shown signs of appearance of a bone callus in the 3rd week after surgery, while the rate has been 40 % in group B. Conclusion: Using nasal spray of calcitonin in old females with intertrochanteric fracture is effective for earlier and increased rate of bone union. KEY WORDS: Calcitonin, Intertrochanteric fractures, Alkaline phosphatase, Fracture union. Pak J Med Sci January - March 2010 Vol. 26 No. 1 54-58 How to cite this article: Sarrafan N, Mehdinasab SA, Dashtbozorg A, Pipelzadeh MR, Pedram H. Short term results of concomitant intranasal administration of Salmon Calcitonin in Intertrochanteric femur fractures operated upon using dynamic hip screw. Pak J Med Sci 2010;26(1):54-58 Correspondence Dr. Seyed Abdolhossein Mehdinasab Associated Professor of Orthopedic Surgery, Emam Khomeini Hospital, Ahvaz, Iran. E-mail: hmehdinasab@yahoo.com * Received for Publication: April 10, 2009 * Revision Received: December 21, 2009 * Revision Accepted: December 22 nd 2009 INTRODUCTION Hip fracture is common in elderly people. The existence of osteoporosis in patients with inter- trochanteric fracture had more effects particu- larly on the outcome of treatment after internal fixation because there is a direct relationship between the rate of osteoporosis and quality of fixation. Therefore the bone content will affect the outcome of treatment.