MOJ Orthopedics & Rheumatology Evaluation of Serum Levels of Copper and Nutritional Factors in Patients with Perthes Disease Submit Manuscript | http://medcraveonline.com Background About a hundred years after the first reports about the disease Legg-Calvé-Perthes that Perthes also called, since it is still the main cause of this disease is unknown. Perthes with the loss of femoral head blood flow in growing children, between the ages of 2-13 years is determined and is considered as a vascular disease. The outbreak, one in every 1,200 children younger than 15 years is. 5-4 times more common in boys than girls. Limping, limb length discrepancy, pain and stiffness in the thigh and hip, leg pain and knee although the disorder often affects the hip joint. Common symptoms of the disease are usually gradual onset. Delay in treatment may cause permanent damage to bone and hip that joint replacement surgery is needed. Children with developmental anomalies are at risk [1]. Patients with moderate short stature, skeletal disproportionity, delayed skeletal maturity [2,3]. Hall et al. have registered disharmony and disproportion in the growth of chicks suffered from a shortage of heavy metals [4] and low serum concentrations of manganese have been but this has not been confirmed [5] gluck et al. reported antithrombin deficiency in patients [6]. Gluck et al. Also reported low fibrinolysis in patients who have smoking parents [7]. There is association between disease and breech birth, low birth weight and parents older than average age [8]. Is a multifactorial inheritance pattern has been proposed [9]. A Nevelas and Burch have been reported [10]. This concept represents less common genetic cause in South Africa by Perthes in blacks compared with whites has been [11]. The results of experimental studies in animals fed with food containing copper and zinc inadequate and also in human have shown that in some range of copper concentration many of symptoms associated with vascular disease. Method In this study blood level of zinc and copper in patient with perthes and control group with minor musculoskeletal trauma who were matched for age and sex were measured. Blood sample were taken through the needle of stainless steel with plastic pistons.3CC minimum volume blood samples to measure the serum was separated from the serum of patients and controls each was diluted with deionized water at a ratio of one to five flame atomic absorption spectrometry (air-acetylene mixture) spread their absorption at a wavelength of 213.8 Nano meters measured concentration of the samples by comparing peak with the peak of the standards used within (lit / mg100, 200, 300 and 400) were determined consumption standards of diluting the volume of appropriate standards save by glycerol diluted (50cc glycerol with deionized water to the volume100 cc they were) were prepared serum levels of copper in the case and control groups after dilution directly serum samples in flame atomic absorption spectrometry (mixture of air and acetylene) scattered and absorbed water “in the wavelength of 324.8 nanometer . size copper concentrations of samples by comparing peak with standard peak usage (0.04 to5 mmol per liter) were determined Prostheses study on 22 patients referred to the orthopedic ward of Imam Khomeini hospital and minor trauma patients admitted hospital Imam Khomeini as the control group in terms of age and sex matched were also statistical software used SPSS software Volume 6 Issue 7 - 2016 1 Professor of Orthopedic Surgery, Department of orthopedic, Ahvaz Jundishapur University of medical science, Iran 2 Assistant professor of orthopedic surgery, Department of orthopedic, Ahvaz Jundishapur University of medical science 3 Orthopaedic surgeon, Department of orthopedic, Ahvaz Jundishapur University of medical science, Iran *Corresponding author: Dr. Mohammad Fakoor, Professor of Orthopedic Surgery, Department of orthopedic Hospital, Ahvaz Jundishapur University of medical science, Iran, Email: Received: April 26, 2016 | Published: December 30, 2016 Research Article MOJ Orthop Rheumatol 2016, 6(7): 00250 Abstract Background: About a hundred years after the first reports about the disease Legg-Calvé-Perthes that Perthes also called, since it is still the main cause of this disease is unknown. Methods: In this RCT study blood level of zinc and copper in patient with perthes and control group with minor musculoskeletal trauma who were matched for age and sex were measured and compared. Results: This study showed that low level of zinc and copper with Perthes patients compared with controls group with minor trauma referring to Imam Khomeini hospital of Ahvaz. Conclusion: In this study lower level of zinc and copper in patient with perthes compared to control was demonstrated but zinc deficiency and copper to investigate the etiologic relationship with perthes disease requires further investigation. That the proof of this can be modified nutritional pattern of children with perthes disease be prevented.