Journal Pre-proofs Localized Controlled Release of Bevacizumab and Doxorubicin by Thermo- Sensitive Hydrogel for Normalization of Tumor Vasculature and to Enhance the Efficacy of Chemotherapy Haile Fentahun Darge, Abegaz Tizazu Andrgie, Endiries Yibru Hanurry, Yihenew Simegniew Birhan, Tefera Worku Mekonnen, Hsiao-Ying Chou, Wei-Hsin Hsu, Juin-Yih Lai, Shuian-Yin Lin, Hsieh-Chih Tsai PII: S0378-5173(19)30844-0 DOI: https://doi.org/10.1016/j.ijpharm.2019.118799 Reference: IJP 118799 To appear in: International Journal of Pharmaceutics Received Date: 25 July 2019 Revised Date: 5 October 2019 Accepted Date: 13 October 2019 Please cite this article as: H. Fentahun Darge, A. Tizazu Andrgie, E. Yibru Hanurry, Y. Simegniew Birhan, T. Worku Mekonnen, H-Y. Chou, W-H. Hsu, J-Y. Lai, S-Y. Lin, H-C. Tsai, Localized Controlled Release of Bevacizumab and Doxorubicin by Thermo-Sensitive Hydrogel for Normalization of Tumor Vasculature and to Enhance the Efficacy of Chemotherapy, International Journal of Pharmaceutics (2019), doi: https://doi.org/ 10.1016/j.ijpharm.2019.118799 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2019 Published by Elsevier B.V.