April 2009 Vol. 37, No. 4 CONTENTS SHORT COMMUNICATIONS Differential Time- and NADPH-Dependent Inhibition of CYP2C19 by Enantiomers of Fluoxetine. David M. Stresser, Andrew K. Mason, Elke S. Perloff, Thuy Ho, Charles L. Crespi, Andre A. Dandeneau, Ling Morgan, and Shangara S. Dehal ........... 695 Two Novel CYP2D6*10 Haplotypes As Possible Causes of a Poor Metabolic Phenotype in Japa- nese. Masayuki Matsunaga, Hiroshi Yamazaki, Kazuma Kiyotani, Shunsuke Iwano, Jyunji Saru- watari, Kazuko Nakagawa, Akiko Soyama, Shogo Ozawa, Jun-ichi Sawada, Eiji Kashiyama, Mori- toshi Kinoshita, and Tetsuya Kamataki ...... 699 Clonidine Pharmacokinetics in Pregnancy. M. L. Buchanan, T. R. Easterling, D. B. Carr, D. D. Shen, L. J. Risler, W. L. Nelson, D. R. Mattison, and M. F. Hebert ..................... 702 Expression and Localization of Cytosolic Sulfotrans- ferase (SULT) 1A1 and SULT1A3 in Normal Human Brain. Emily D. Salman, Susan A. Kad- lubar, and Charles N. Falany ............ 706 ARTICLES CYP3A4-Mediated Ester Cleavage as the Major Meta- bolic Pathway of the Oral Taxane 3'-tert-Butyl-3'- N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl- 3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183). Donglu Zhang, Van T. Ly, Michael Lago, Yuan Tian, Jinping Gan, W. Griffith Hum- phreys, and S. Nilgu ¨n C ¸o ¨mezog ˘lu ........... 710 A Phosphomimetic Mutation at Threonine-57 Abol- ishes Transactivation Activity and Alters Nuclear Localization Pattern of Human Pregnane X Re- ceptor. Satyanarayana R. Pondugula, Cynthia Brimer-Cline, Jing Wu, Erin G. Schuetz, Rakesh K. Tyagi, and Taosheng Chen ............ 719 Vascular Perfused Segments of Human Intestine as a Tool for Drug Absorption. Yansheng Wei, Liomar A. A. Neves, Tammy Franklin, Nadya Klyuchni- kova, Benjamin Placzek, Helen M. Hughes, and C. Gerald Curtis ..................... 731 Silencing the Breast Cancer Resistance Protein Expres- sion and Function in Caco-2 Cells Using Lentiviral Vector-Based Short Hairpin RNA. Wei Zhang, Jibin Li, Samantha M. Allen, Erica A. Weiskircher, Yuehua Huang, Rebecca A. George, Ramon G. Fong, Albert Owen, and Ismael J. Hidalgo ..... 737 Mechanistic Analysis of the Inactivation of Cyto- chrome P450 2B6 by Phencyclidine: Effects on Substrate Binding, Electron Transfer, and Uncou- pling. Mohamad Shebley, Ute M. Kent, David P. Ballou, and Paul F. Hollenberg ........... 745 Receptor Occupancy and Brain Free Fraction. Jeanette Watson, Sara Wright, Adam Lucas, Kirsten L. Clarke, Jean Viggers, Sharon Cheetham, Phil Jeffrey, Rod Porter, and Kevin D. Read ....... 753 Metabolism of Vitamin D2 to 17,20,24-Trihydroxyvi- tamin D2 by Cytochrome P450scc (CYP11A1). Minh N. Nguyen, Andrzej Slominski, Wei Li, Yun Rui Ng, and Robert C. Tuckey ............ 761 Dopamine Is a Low-Affinity and High-Specificity Substrate for the Human UDP-Glucuronosyl- transferase 1A10. Katriina Ita ¨aho, Michael H. Court, Pa ¨ivi Uutela, Risto Kostiainen, Anna Radominska-Pandya, and Moshe Finel ...... 768 Disposition of the Herbicide 2-Chloro-4-(ethyl- amino)-6-(isopropylamino)-s-triazine (Atrazine) DRUG METABOLISM AND DISPOSITION A Publication of the American Society for Pharmacology and Experimental Therapeutics Drug Metabolism and Disposition (ISSN 0090-9556) is published monthly (one volume per year) by the American Society for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20814-3995; e-mail: subscriptions@aspet.org; web site: aspet.org. Periodicals postage paid at Bethesda, MD, and at additional mailing offices. POSTMASTER: Send address changes to Drug Metabolism and Disposition, 9650 Rockville Pike, Bethesda, MD 20814-3995. Subscription rates: U.S.: $400.00; outside the U.S.: $479. Single copy: $36. GST Tax Number for Canadian subscribers: BN:13489 2330 RT, Indexed or abstracted by Biochemistry & Biophysics Citation Index®, Biological Abstracts, BIOSIS Previews Database, BioSciences Information Services, Current Awareness in Biological Sciences, Current Contents®/Life Sciences, EMBASE/Excerpta Medica, Index Medicus, International Pharmaceutical Abstracts, Medical Documentation Service®, Reference Update®, Research Alerts®, Science Citation Index®, SciSearch®, and SIIC Data Bases Copyright © 2009 by the American Society for Pharmacology and Experimental Therapeutics. All rights reserved. Printed in the U.S.A. Continued on next page at ASPET Journals on December 5, 2021 dmd.aspetjournals.org Downloaded from