This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/CNCR.33216 This article is protected by copyright. All rights reserved DR. NEETA SOMAIAH (Orcid ID : 0000-0002-0146-7732) DR. BRIAN A. VAN TINE (Orcid ID : 0000-0003-4572-6668) DR. ELIZABETH GARRETT-MAYER (Orcid ID : 0000-0003-4709-0333) DR. SCOTT M SCHUETZE (Orcid ID : 0000-0002-7167-4163) DR. WILLIAM LEWIS READ (Orcid ID : 0000-0001-6946-5250) DR. ANDREW S KRAFT (Orcid ID : 0000-0003-3417-4845) Article type : Original Article A Randomized, Open-label, Phase II, Multi-center Trial of Gemcitabine with Pazopanib or Gemcitabine with Docetaxel in Advanced Soft Tissue Sarcoma Running title: Combination Drug Therapy for Sarcoma Neeta Somaiah, MD 1 , Brian Andrew Van Tine, MD PhD 2 , Amy E. Wahlquist, MS 3 , Mohammed M. Milhem, MD 4 , Elizabeth G. Hill, PhD 3 , Elizabeth Garrett-Mayer, PhD 5 , Kent E. Armeson, MS 3 , Scott M. Schuetze, MD 6 , Christian F. Meyer MD 7 , Daniel Y. Reuben MD 3 , Anthony D. Elias MD 8 , William L. Read, MD 9 , Sant P. Chawla, MD 10 , and Andrew S. Kraft, MD 11* 1 Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX; 2 Washington University School of Medicine in St. Louis, St. Louis, MO; 3 Medical University of South Carolina, Charleston, SC; 4 University of Iowa, Iowa City, IA; 5 Center for Research and Analytics, American Society of Clinical Oncology, Alexandria, VA; 6 University of Michigan, Ann Arbor, MI; 7 Johns Hopkins Hospital, Baltimore, MD; 8 University Author Manuscript