Accepted Manuscript Construction of a Pichia pastoris strain efficiently secreting irisin and assessment of its bioactivity in HepG2 cells Xiaodan Li, Huikun Duan, Qiqi Liu, Muhammad Umar, Wenya Luo, Xingkai Yang, Jianhong Zhu, Minggang Li PII: S0141-8130(18)33331-2 DOI: https://doi.org/10.1016/j.ijbiomac.2018.11.092 Reference: BIOMAC 10969 To appear in: International Journal of Biological Macromolecules Received date: 3 July 2018 Revised date: 11 October 2018 Accepted date: 11 November 2018 Please cite this article as: Xiaodan Li, Huikun Duan, Qiqi Liu, Muhammad Umar, Wenya Luo, Xingkai Yang, Jianhong Zhu, Minggang Li , Construction of a Pichia pastoris strain efficiently secreting irisin and assessment of its bioactivity in HepG2 cells. Biomac (2018), https://doi.org/10.1016/j.ijbiomac.2018.11.092 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.