Accepted Manuscript Fish embryo toxicity test, threshold approach, and moribund as approaches to implement 3R principles to the acute fish toxicity test ZhiChao Dang, Leo TM. van der Ven, Anne S. Kienhuis PII: S0045-6535(17)31270-5 DOI: 10.1016/j.chemosphere.2017.08.047 Reference: CHEM 19745 To appear in: Chemosphere Received Date: 08 June 2017 Revised Date: 04 August 2017 Accepted Date: 10 August 2017 Please cite this article as: ZhiChao Dang, Leo TM. van der Ven, Anne S. Kienhuis, Fish embryo toxicity test, threshold approach, and moribund as approaches to implement 3R principles to the acute fish toxicity test, (2017), doi: 10.1016/j.chemosphere.2017.08.047 Chemosphere This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.