Journal of Cancer Therapy, 2020, 11, 715-721 https://www.scirp.org/journal/jct ISSN Online: 2151-1942 ISSN Print: 2151-1934 DOI: 10.4236/jct.2020.1111060 Nov. 23, 2020 715 Journal of Cancer Therapy Acute Lymphoblastic Leukemia in Childhood Following Pyoderma Gangrenosum Aziza El Ouali 1 *, Manal Azizi 1 , Nadia Bouhafs 1 , Mounia Rimani 2 , Ayad Ghannam 1 , Abdeladim Babakhouya 1 , Maria Rkain 1 , Noufissa Benajiba 1 1 Hematology and Oncology Unit, Departments of Pediatric, UHC Mohammed VI, Medical School of OUJDA, University Mohamed I, Oujda, Morocco 2 Hassan Pathological Anatomy Center, Rabat, Morocco Abstract Pyoderma gangrenosum (PG) is a rare but serious ulcerating skin disease that occurs either idiopathically or associated with various systemic diseases and malignant tumors. Although the association of PG with myeloid malignant tumors is well known, their association with lymphoid malignant tumors, es- pecially in children is extremely rare. We present here a case of PG in a 4-year and 4 months female child, diagnosed in the Pediatrics department, which had initially evolved well with oral corticosteroid therapy and a local dermo- corticoid. The development was marked 7 months after stopping corticoste- roid treatment by the occurrence of acute lymphoblastic leukemia. This case of PG is presented in the intention of increasing awareness of this uncommon condition with may occurring in association with haematological malignancy. PG may precede, develop concurrently with, or follow various conditions. Keywords Pyoderma Gangrenosum, Childhood, Leukemia 1. Introduction Pyoderma gangrenosum is a rare, ulcerative, cutaneous condition, which was first described in 1930, by Brun-Sting et al. [1]. It usually occurs between the ages of 25 and 54 and rarely affects children. It is most commonly seen in pa- tients with chronic inflammatory bowel disease, gammopathies [2] [3], rheu- matoid arthritis, diabetes mellitus, myelodysplastic syndrome and myeloid leukemia. Although the association of PG myeloid malignancies is well known, its association with lymphoid malignancies, particularly in children is ex- How to cite this paper: El Ouali, A., Azizi, M., Bouhafs, N., Rimani, M., Ghannam, A., Babakhouya, A., Rkain, M. and Benajiba, N. (2020) Acute Lymphoblastic Leukemia in Childhood Following Pyoderma Gan- grenosum. Journal of Cancer Therapy, 11, 715-721. https://doi.org/10.4236/jct.2020.1111060 Received: May 27, 2020 Accepted: November 20, 2020 Published: November 23, 2020 Copyright © 2020 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access