Journal of Namibian Studies, 33 S2(2023): 3422–3437 ISSN: 2197-5523 (online) 3422 Efficacy and Safety of Topical Botanical Cream in the Treatment of Psoriasis: A Randomized Controlled Study Wantika Kruanamkam 1 , Pichit Boonkrong 2 , Phongvarin Naksaranyuyottana 3 , Pataweekorn Ketkomol 4 , Thaval Rerksngarm 5 , Thanvisith Charoenying 6 14 Pharmacology and Toxicology Unit, Department of Medical Sciences, Faculty of Science, Rangsit University, Pathum Thani, Thailand 2 College of Biomedical Engineering, Rangsit University 3 Faculty of Optometry, Rangsit University, Pathum Thani, Thailand 5 Faculty of Allied Health Sciences, Pathumthani University, Pathum Thani, Thailand 6 Faculty of Allied Health Sciences, Pathumthani University, Pathum Thani, Thailand, thanvisith.c@ptu.ac.th Abstract This study evaluated the efficacy and safety of a topical botanical cream containing a combination of herbs for the treatment of psoriasis, a chronic inflammatory skin disease that can considerably diminish the quality of life of a patient. Although numerous topical therapies are available, the majority rely on potentially dangerous steroid creams or coal tar ointments that require a doctor's prescription. In this setting, safe and effective alternative treatments are required. The purpose of this study was to evaluate the efficacy and safety of a topical botanical cream containing a combination of herbs for the treatment of psoriasis. A randomized controlled trial including 51 patients with plaque psoriasis was done. Patients were administered the topical cream for eight consecutive weeks, with the dosage decided by the afflicted skin area. Patients' quality of life was measured using the Psoriasis Disability Index (PDI) and Dermatology Life Quality Index (DLQI). The patients in the therapy group reported a significant reduction in psoriasis severity, as judged by the PASI, according to the study results. The symptoms began to ease as early as the second week of cream use. In addition, as measured by the PDI and DLQI, the patients' quality of life increased. By the sixth week, the DLQI