This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/1440-1681.13252 This article is protected by copyright. All rights reserved DR. SAAD LAHLOU (Orcid ID : 0000-0002-9070-5009) PROF. GLÓRIA PINTO DUARTE (Orcid ID : 0000-0003-3971-7976) Article type : Original Article GQ-130, a novel analogue of thiazolidinedione, improves obesity-induced metabolic alterations in rats: evidence for the involvement of PPARβ/δ pathway Odair Alves Silva a , Helder Veras Ribeiro-Filho b , Thayna Mendonca Avelino b , Thais Helena Tittanegro b , Ana Carolina Migliorini Figueira b , Luiza Antas Rabelo c , Ivan da Rocha Pitta d , Saad Lahlou e , Glória Pinto Duarte a,* a Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, 50670- 901, Brazil b National Institute of Biosciences, Brazilian Association for Synchrotron Light Technology, Campinas, São Paulo 13083-970, Brazil c |Institute of Biological Sciences and Health, Federal University of Alagoas, Maceio, 57072- 900, Brazil d Core of Therapeutic Innovation, Federal University of Pernambuco, Recife, 50670-901, Brazil e Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, 60430-270, Brazil Accepted Article