htps://FARMA.com.ro | Romanian Journal of PHARMACEUTICAL PRACTICE | 41 Pre-COVID19 pandemia vaccines could have a nonspecifc efect in preventng SARS-CoV-2 infecton in the pediatric populaton Vlad DIMA 1 , George IANCU 2,3 , Roxana-Elena BOHILTEA 2,3 , Raluca Mariana STANESCU 4 , Adrian Ioan TOMA 5 , Valentn-Nicolae VARLAS 2,3 , Ana-Maria DAVITOIU 3,6 1 Department of Neonatology, Filantropia Clinical Hospital, Bucharest, Romania 2 Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania 3 “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 4 “Alessandrescu-Rusescu” Natonal Insttute for Mother and Child Health, Bucharest, Romania 5 Memorial Life Hospital, Bucharest, Romania 6 “Victor Gomoiu” Clinical Hospital, Bucharest, Romania Ref: Ro J Pharm Pract. 2022;15(2) DOI: 10.37897/RJPhP.2022.2.1 Corresponding author: Vlad Dima E-mail: dima.vlad@yahoo.com Abstract The COVID-19 pandemic raised an unexpected challenge for the medicine and pharmaceutical industry. The primary goal in a short timeframe was to fght the spreading of SARS-CoV-2 by any means, starting from social distancing, wearing face masks, and, in the end, fnding a vaccine as efective as possible in preventing the virus spread. Studies were published from the frst months of the pandemic, trying to show the way that this virus atacks the host and how it is transmited in communities. Some data were contradictory, but one fact became obvious – children have a lower risk of infection with SARS-CoV-2. Data collected from many studies showed that some vaccines that were already in use before the COVID-19 pandemics are efcient in preventing SARS-CoV-2 infection. In this paper, we tried to summarize the nonspecifc efects of preexisting vaccines against SARS-CoV-2 infection. Keywords: COVID-19, children, vaccines, nonspecifc efects, studies INTRODUCTION SARS-CoV-2 is responsible for the COVID-19 pandemic that was first identified in China at the end of 2019 and rapidly spread worldwide [1]. Children represent a small part of all patients with COVID-19 [2]. The number of children presenting to hospitals decreased during the pandemic due to isolation, reduced circulation of transmittable diseases, and increased anxiety regarding hospitals [3]. Children faced a change in their social and family life, mostly due to the closure of schools, a measure implemented in most countries around the world to reduce the impact of the pandemic [4]. The immunological mechanisms that lead to a lower spread or severity in children and adolescents are not completely clarified. The immune modification encountered in those children who had Artcle History: Received: 21 June 2022 Accepted: 24 June 2022 ORIGINAL RESEARCH PAPERS