©Innovations in Pharmaceuticals and Pharmacotherapy, All rights reserved Innovations in Pharmaceuticals and Pharmacotherapy www.innpharmacotherapy.com eISSN: 2321–323X Abstract The occurrence of gallbladder cancer rare in United States and other western countries is increases. In fact, more than half of those patients die. Many patients do not receive palliative chemotherapy or adequate therapy. The question of whether a combined chemotherapy is better than a single drug-like gemcitabine. The objective of this prospective study was to compare the haematological toxicity between cisplatin-5-fluorouracil and gemcitabine-cisplatin used in treatment of gallbladder cancer at Mahavir Cancer Institute and Research Centre Phulwari Sharif Patna, Bihar. Toxicities were graded as per the National Cancer Institute Common Toxicity Criteria (NCI-CTC), grade I, II, III and IV. Anaemia of grade III-IV was observed 11% and 7% respectively of cycles of chemotherapy in cisplatin-5-fluorouracil, while in cisplatin- gemcitabine observe 13% and 4% respectively. Grade III-IV thrombocytopenia was more frequently in the cisplatin-5-fluorouracil chemotherapy cycle (2% & 1.3% respectively) compared with the cisplatin-gemcitabine (2.6% and 0% respectively). Grade III-IV neutropenia also occurred more frequently in cisplatin-5-fluorouracil (5.3% and 5.3% respectively) than in the cisplatin-gemcitabine respectively. However, the lack of statistical significance results in the present study may be due to inadequate sample size (8 in each Arm). As far as safety is concerned, cisplatin-5-fluorouracil seems to be safer than cisplatin-gemcitabine. Keywords: Ketorolac Tromethamine, Solid Dispersion, Surfactants and Carriers. *Corresponding Author: Md. Daud Ali, M Pharmacy, Department of Pharmacy Practice National Institute of Pharmaceutical Education & Research, Hajipur India. Email-dali.niper@gmail.com 1. Introduction Even though gallbladder cancer is a rare disease, it is estimated that close to 7,000 new cases occur annually in the United States [1]. Gallbladder cancer is an aggressive tumor with a poor prognosis. It is uncommon in the western world, with approximately 5,000 cases of gallbladder carcinoma annually in the USA [1,2]. Worldwide, the highest prevalence of gallbladder cancer is seen in Israel, Mexico, Chile, Japan, and among Native American women, particularly those living in New Mexico [2,3,6,9]. In Indian scenario a study conducted by the International Hepato-Pancreato Biliary Research Article Comparison of Hematological Toxicity Between Cisplatin-5-Fluorouracil and Gemcitabine-cisplatin used in Treatment of Gallbladder Cancer Mohd Daud Ali*, Hemant Sharma, Mohd Asif, Farhat Yasmin, Md. Sarfaraz Alam Mahavir Cancer Institute and Research Centre Phulwari Sharif Patna, Bihar, India IPP