Open Access, Volume 2 Bone metastases from renal cell carcinoma: A case report and literature review Case Report www.jcimcr.org Journal of Clinical Images and Medical Case Reports Received: Sep 28, 2021 Accepted: Nov 18, 2021 Published: Nov 25, 2021 Archived: www.jcimcr.org Copyright: © Nefss M (2021). DOI: www.doi.org/10.52768/2766-7820/1426 *Corresponding Author: Mouadh Nefss Faculty of Medicine of Tunis, Department of Ortho- pedic Surgery, Mongi Slim Marsa University Hospital, University of Tunis El Manar, Tunis, Tunisia. Email: mouadhnefss2@gmail.com ISSN 2766-7820 Introducton Bony metastases revealing renal cell carcinoma (RCC) is a common situaton since bone is the second site of metastasis afer the lung for this tumor [1,2]. Because of its low sensibility to radiotherapy and chemotherapy, management of such ma- lignant tumor and its spread to bone is stll problematc espe- cially in case of multple metastases [2]. Improvement of Overall Survival (OS) and quality of life, tumor control and to a lesser degree eradicaton of the disease is the main therapeutc goals Mouadh Nefss*; Hichem Abid; Mohamed Amine Gharbi; Ramzi Bouzidi; Khelil Moncef Ezzaouia; Anis Tebourbi Faculty of Medicine of Tunis, Department of Orthopedic Surgery, Mongi Slim Marsa University Hospital, Tunis, University of Tunis El Manar, Tunisia. Abstract Management of bone metastases from Renal Cell Carcinoma (RCC) has signifcantly changed afer the era of targeted therapy that im- proved the overall survival. This has sucked the diferent interven- ers in their management to push the surgical indicatons in order to improve outcome and quality of life for these patents. In case of a solitary metastasis or a limited number of resectable metastases wide resectons have to be considered according to patent profle, comor- bidites, localizaton, heaviness of the surgery and to beneft –risk bal- ance. However such surgeries are highly demanding procedures that must be carefully planned and discussed in multdisciplinary team and with patent. Thus, surgical decision-making for a second metas- tasis and according to what criteria remains a subject of controversy. We report a case of an aggressive metastatc renal cell carcinoma with good functonal and oncologic outcomes 3 years afer surgery coupled with ant-angiogenic treatment. A review of the literature concerning recent attudes in the management of bony metastatc renal carcinoma was carried out. Keywords: renal cell carcinoma; bone metastases; surgery; targeted therapy. Abbreviatons: RCC: Renal Cell Carcinoma; OS: Overall Survival; CT Scan: Computed Tomography Scanner; MRI: Magnetc Resonance Im- aging; TAP: Thoracic Abdominal Pelvic; RT: Radiotherapy. in such case. Recently the use of targeted therapies coupled or not with surgery has changed the prognosis of this pathology through the improvement of OS which prompted oncologists and surgeons to push surgical indicatons while taking into ac- count the beneft to risk rato for the patent. We report a case of a young adult with aggressive bony metastases from RCC which had a good outcome afer aggressive surgeries coupled to ant-angiogenic therapy. Recent attudes in the management of bony metastatc renal carcinoma were revealed through review of the literature.