Int.J.Curr.Microbiol.App.Sci (2015) 4(5): 1132-1138 1132 Original Research Article Sero-Prevalence of Viral Transfusion-transmissible Infections among Blood Donors at Kosti Teaching Hospital, White Nile State/Sudan Elsharif Ahmed Bazie 1 *, Moataz Mohamed Alhasan Ali 1 , Hamza Babikir Hamza 2 , Omer Saeed Magzoub 3 , Mutasim Siddig Mohammed Salih 4 and Bader Eldien Haroun 5 1 Department of Pathology, Faculty of Medicine and Health Sciences, Alimam Almahdi University, Sudan 2 Department of Medicine, Faculty of Medicine and Health Sciences, Alimam Almahdi University, Sudan 3 Department of Paediatrics & Child Health, Nile College, Khartoum, Sudan 4 Department of Clinical Pharmacology, Faculty of Medicine and Health Sciences, Alimam Almahdi University, Sudan 5 Department of Radiology, Faculty of Medicine and Health Sciences, Alimam Almahdi University, Sudan *Corresponding author ABSTRACT Introduction Blood donation saves millions of lives. This is due to its crucial role in the supportive care of medical and surgical patients. However, unsafe transfusion practices may increase the risk of transfusion-transmissible infections (TTIs like Hepatitis viruses (HBV, HCV), Human immune deficiency virus (HIV) (A C Shrestha, P Ghimne, B R Tiwari, et al 2009). Proper monitoring and selection of voluntary donors and, testing the donated blood for specific antibodies for infectious agents, can largely reduce the risk of TTIs (Lt Col PK Gupta, Col H Kumar, Basannar, Brig M Jaiprakash, 2006). It is ISSN: 2319-7706 Volume 4 Number 5 (2015) pp. 1132-1138 http://www.ijcmas.com This study aimed to determine the Sero-prevalence of viral transfusion-transmissible infectious diseases among blood donors, namely immunodeficiency virus, hepatitis B and C virus among blood donors. The study was carried out in the blood bank at Kosti Teaching Hospital, White Nile State, Sudan. Screening of blood samples for hepatitis B surface antigen (HBsAg), human immunodeficiency virus (HIV) and hepatitis C virus (HCV) antibodies were done using immune-chromatographic (ICT) strips. The study included 1204 blood donors. All were males. The overall prevalence of viral transfusion transmissible infections was 115 (9.6%). The sero-prevalence for antibodies against HIV and hepatitis C virus was positive in 8 (0.7%) and 41 (3.4%) donors respectively while HBsAg was detected in 66 (5.5%) donors. This study showed that the sero-prevalence of hepatitis B and C viruses was high in the community local to Kosti hospital, a situation that reaffirms the need for strict criteria for selection of blood donors and also methods of laboratory assays for detection of infectious agents must be improved. In addition; appropriate management must be ensured to prevent the further transmission of these infections. Keywords Transfusion- transmitted infections (TTIs), Immunodeficien cy virus (HIV), Hepatitis B virus (HBV), Hepatitis C virus (HCV)