Posters, Varia (V) S65 141V Relationship between neuropathy and nephropathy in children with type 1 diabetes M. Wysocka-Mincewicz 1 , E. Piontek 1 , I. Gromek 2 , S. J´ o´ zwiak 2 , J. Skwarzec 1 . 1 Department of Metabolic Diseases, Endocrinology and Diabetology, The Children’s Memorial Health Institute, Warsaw, Poland, 2 Department of Neurology and Epileptology, The Children’s Memorial Health Institute, Warsaw, Poland Diabetic neuropathy and nephropathy are serious late complications. The aim of the study was to detect the relationships between the function of peripheral nerves and kidneys in children with type 1 diabetes. Material and Methods: 45 children with type 1 diabetes were included in the study (25 girls and 20 boys, mean age 14.68±3 years, mean HbA1c 8.38±1.6%, mean duration of diabetes 4.96±3.3 years). In all cases neurological examination and nerve conduction studies of motor (median, ulnar, tibial and peroneal) and sensory nerves (median, ulnar and sural) with standard techniques were done. For testing influence on whole nervous system sum of results from all tested nerves were taken to analysis. Microalbuminuria in 24-hour urine collection and creatinemia current and mean for diabetes duration were tested. Analyses of Pearson or Spearman Rank R correlations depending on normality of distribution were conducted. Results: In the studied group correlation between creatinemia and sum of conduction velocities in all tested nerves (r = -0.35, p < 0.05), sum of sensory latencies (r = 0.39, p < 0.02) and sum of latencies of wave F (r = 0.39, p < 0.02) were detected. Mean of creatinemia for all diabetes duration significant correlate with sum of conduction velocities (r = -0.35, p < 0.05). The study revealed significant correlation between microalbuminuria and distal latency in peroneal (r = 0.4, p < 0.02), and F wave latencies in peroneal (r = 0.36, p < 0.05) and tibial nerves (r = 0.34, p < 0.05). Conclusions: In the studied population of children with type 1 diabetes negative relations between creatine and conduction velocity were detected, and between microalbuminuria and latencies in motor nerves. This data indicate on the strong relationship between neuropathy and nephropathy in type 1 diabetes. 142V Electroclinical diagnosis in early onset retinal dystrophies V. Vianello Dri 1 , A. Cappellari 1 , L. Pinello 2 , P. Maimone 2 , P.A. Battistella 3 . 1 Clinical Neurophysiology Department, Children s Hospital, University of Padua, Italy, 2 Clinical Ophthalmology Department, Children s Hopspital, University of Padua, Italy, 3 Paediatric Neurology Department, Children’s Hospital, University of Padua, Italy The aim of this study is to describe the clinical presentation and electrophysiological diagnostic features in a group of patients with paediatric onset retinal dystrophies and to estimate the time-lag from clinical onset to electro-clinical diagnosis. Study population consists of 50 patients (30 males) referred to the Department of Clinical Neurophysiology at a median age of 3.5 years (range 5 months 14 years). All patients under- went a paediatric ophthalmological examination, photopic and scotopic Electroretinogram and Visual Evoked Potentials at diagnosis and during follow-up. The electro-clinical diagnosis was Rod Cone Distrophy (34%), Achromatopsia (26%), Cone Rod Distrophy (24%), Congenital Stationary Night Blindness (6%) and Leber’s Congenital Amaurosis (4%). In the majority of cases (68%) the clinical onset was before 6 months, the first symptom being nystagmus (76% of cases), followed by reduced visual acuity (28%). Nystagmus was an early and consistent feature also analysing electro-clinical subgroups. The mean time elapsed between the clinical onset and the 1st medical contact was 6.8 months, but from the clinical onset to the electro-clinical diagnosis (1st ERG) the mean time elapsed was 3.9 years. In conclusion the combination of clinical features at onset, paediatric ophtalmological assessment and visual electrophyisiological evaluation of stationary or progressive course at follow-up allowed the electroclinical diagnosis in 100% of cases. We suggest that early onset of nystamus should prompt appropriate testing for early diagnosis of retinal distrophies. The visual electrophysiological evaluation is and extremely specific and powerful tool in the diagnostic work-up of the retinal diseases. Knowledge of electroclinical patterns of retinal dystrophies can help the early recognition of retinopathies occurring as a part of the clinical spectrum of genetic or metabolic syndromes in the field of paediatric neurology. 143V Etiology and trigger factors in childhood headache G. Dizdarer, N. Cetin, Z. Sahbudak, M. Yildirimer, N. Aksu. Tepecik Teaching and Research Hospital Department of Pediatrics and Pediatric Neurology, ˙ Izmir, Turkey Headache is a major health problem that influences the quality of life in children and their parents. Three hundred children who applied to pediatric neurology outpatient concerning about headache were included in this study. Patients were observed according to their sociodemographic characteristics, etiology and triggers factors. Headaches were classified according to the criteria of the “International Headache Society”. Headache seems to come out more often on girls (63.1%) than boys and between the ages of 10-14. While migraine (42.8%) was the primary cause of the headache, the second important one was cluster headache (25.2%). On the follow up period trigger factors have been able to be detected in one hundred thirty patients. The research results showed that hunger (60.8%) and sleeplessness (63.8%) were the main factors effecting headache and also some relation between diet and headache was determined. The trigger factors could be defined more clearly with the increase of the researches related with this subject. 144V Intractable postural headache in an adolescent with Marfan syndrome. Case report B. Rosdy 1 , K. Koll´ ar 1 , J. M´ oser 1 , M. Kord´ as 2 , G. V´ arallyay 3 . 1 Paul Heim Children’s Hospital, Hungary, 2 National Institute for Neurosurgery, Hungary, 3 Semmelweis Medical University, Budapest, Hungary We describe a 16 year old adolescent female newly diagnosed with Marfan syndrome, who presented with intractable postural headache. Postural headache rarely accompanies Marfan syndrome. Its cause is probably the connective tissue disorder, which predisposes the patient to meningeal diverticula. Possibly after minor unrecognised head trauma or secondary to Valsalva manoeuvre CSF leak from meningeal diverticula can happen. Our patient’s brain MRI showed bilateral frontal subdural ef- fusion, narrow ventricles, enlarged cervical venous plexi and dural ectasias. Radionuclide cisternography demonstrated CSF leaks at multiple sites. She could not be treated conservatively, but was successfully treated by epidural saline injections. Control brain and cervical MRI confirmed her healing, too. At the two year follow up visit, she was completely well.