International Journal of Research in Medical and Clinical Sciences 1 Introduction Previously, we were able to show that an increase in metabolic age compared to chronological age is an indicator of systemic dysmetabolism [1]. However, the extent to which systemic metabolism is associated with local liver dysmetabolism remains unclear. At the same time, the assessment of liver changes associated with dysmetabolism is significant practical importance for the accurate detection of metabolically associated fatty liver disease (MAFLD). Liver steatosis and fibrosis patients are at increased risk of progressive fibrosis and cirrhosis, and the condition represents the second leading cause of liver transplant. In this study, we present the parallel analysis systematization results in the biological age(metabolic -Met-age), steatosis (S) and liver fibrosis(F). Method All study participants in this prospective study were Caucasian. 20 practically healthy persons with chronological age (Chr-age) = mean 40.4 (95% CI=30.8-49.9), median 39 (Q25/75=28-51). M/F = 6/20 (30.0%/70.0%), and 31 patients with hepatomegaly (ICD-11: ME10.00 Hepatomegaly, not elsewhere classified. Definition: Hepatomegaly is swelling of the liver beyond its normal size) referred for transient elastography (FibroTouch in iLivtouch FT 100). S and F was measured in each patient according to the manufacturer’s recommendations. Steatosis and fibrosis staging sections recommended by the manufacturer were used. Additionally, each participant underwent bioimpedancemetry (BIM) (tetrapolar, multifrequency and vector analysis) with the determination of body mass composition. International Journal of Research in Medical and Clinical Science Volume 1, Issue 2, 2023, PP: 01-04 www.journalserapublications.com Research Article Clinical Aspects for Mutual Relations between Biological Age, Steatosis and Liver Fibrosis Marakhouski Y.K. 1 , Vasileuskaya S.A. 2 1,2 Department of Gastroenterology and Nutritiology, Belarusian Medical Academy of Postgraduate Education, Minsk, Belarus. Abstract In this study, we present the parallel analysis systematization results in the biological age(metabolic -Met-age), steatosis (STe) and liver fbrosis(F). 20 practically healthy persons with chronological age (Chr-age) = mean 40.4 (95% CI=30.8-49.9), median 39 (Q25/75=28-51). M/F = 6/20 (30.0%/70.0%), and 31 patients with hepatomegaly (ICD-11: ME10.00 Hepatomegaly, not elsewhere classifed. In practically healthy persons the incidence of severe steatosis is 45%, however, a signifcant suspicion of the presence steatosis can be diagnosed by the diference more than 2 years between metabolic and chronological age, with sensitivity- 86% (95%CI= 49 – 97); specifcity-83% (95%CI= 44 – 97). Individuals with hepatomegaly have signifcantly higher values of liver fbrosis (median = 8,8 kPa (Q25/75=7,0-12,9 vs 6,1kPa (Q25/75=5,7-6,4) and a more frequent spread of severe liver fbrosis (35,5% at 95%CI =19,2-54,6 indicated fbrosis F3-4 vs 0%). Present the possibility using a non-invasive assessment of metabolic age according to bioimpedancemetry data to predict the presence of steatosis in practically healthy individuals and steatosis with fbrosis in individuals with hepatomegaly has been shown for the frst time. Keywords: Metabolic Dysfunction; Noninvasive tests; Liver steatosis and fbrosis; Metabolic age. *Corresponding Author: Marakhouski Y.K., Department of Gastroenterology and Nutritiology, Belarusian Medical Academy of Postgraduate Education, Minsk, Belarus.