Available online at www.ilns.pl International Letters of Natural Sciences 6 (2015) 12-26 ISSN 2300-9675 Abortifacient and Antioxidant Activities of Avicennia marina Muppaneni Srikanth 1 *, Battu Ganga Rao 2 , Mallikarjuna Rao Talluri 3 , T. Rajananda Swamy 4 1 Avanthi College of Pharmacy, Visakhapatnam, Andhra Pradesh, India 2 AU College of Pharmacy, Visakhapatnam, Andhra Pradesh, India. 3 Department of Biology, Adigrat University, Adigrat, Ethiopia. 4 AU College of Pharmacy, Visakhapatnam, Andhra Pradesh, India. *E-mail address: drsrikanthphd2014@gmail.com ABSTRACT The current study was intended to evaluate abortifacient and antioxidant activity of Avicennia marina leaves extracts. Abortifacient activity was evaluated in rats, compared with standard drug (Mifepristone) and antioxidant activity was evaluated by using three free radicals (Superoxide, Hydroxyl and DPPH) compared with Ascorbic acid. The extracts were showed pre implantation loss, post implantation loss of implantations and decreased the survival ration of foetuses. Among all extracts hydroalcoholic extract showed better activity. The selected plant extracts showed concentration dependent percentage inhibition of free radicals. Among three extracts hydroalcoholic extract showed better activity with IC 50 values on superoxide, hydroxyl and DPPH radicals were 203µg, 237µg and 143µg. From the results obtained during the study it the hydroalcoholic extract was used for the isolation of pure compounds, and isolated the different compounds (β-sitosterol, Lupeol and Betulinic acid). Keywords: Avicennia marina; Abortifacient activity; Free radicals; Antioxidant Activity 1. INTRODUCTION Medicinal plants will continue to provide a source for generating novel drug compounds. Plants may become the base for the development of a new medicine or they may be used as phyto-medicine for the treatment of disease [1]. Majority of the present day diseases are due to the shift in the balance of the pro-oxidant and the antioxidant homeostatic phenomenon in the body. The antioxidant defense systems can only protect the body when the amount of free radicals are within the normal physiological level; but when this balance is shifted towards more of free radicals, it leads to oxidative stress which may result in tissue injury and subsequent diseases [2]. Abortifacient agents obtained from indigenous medicinal plants would be of immense benefit especially to inhabitants of developing countries, since the cost of these drugs would