Release study of Naproxen, A Modern drug from pH Sensitive Pullulan Acetate Microsphere Mishra Bishwambhar and Suneetha V * School of Biosciences and Technology, VIT University, Vellore, Tamilnadu, India Key words: Pullulan, Aureobasidium sps., Naproxen, Phosphate Buffer Saline, pH How to Cite this Paper: Mishra Bishwambhar and Vuppu Suneetha* “Release study of Naproxen, A Modern drug from pH Sensitive Pullulan Acetate Microsphere” Int. J. Drug Dev. & Res., October-December 2012, 4(4): 184-191. Copyright © 2012 IJDDR, Vuppu Suneetha et al. This is an open access paper distributed under the copyright agreement with Serials Publication, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1. INTRODUCTION Controlled drug delivery systems, which are used to deliver drugs at predetermined rates at predefined time periods, have been used to overcome the shortcomings of various conventional drug formulations [1,2] . There is a significant progress which has been made in the controlled drug delivery system, more advances are yet to be made for the International Journal of Drug Development & Research | October-December 2012 | Vol. 4 | Issue 4 | ISSN 0975-9344 | Available online http://www.ijddr.in Covered in Official Product of Elsevier, The Netherlands SJR Impact Value 0.03 & H index 2 ©2012 IJDDR Abstract The current study represents the latest and new advances in the investigations and applications of the pullulan the wonderful biomaterial which is produced from microbes (generally Aureobasidium sps.) and its derivatives for its applications in the development of various therapeutic formulations. Basically pullulan is an exo-polysacharides which is non-carcinogenic, non-immunogenic and non-mutagenic without having any types of toxicological activities. Similar to dextran and other biopolymer it can be used as a plasma expander. The model drug for this studies i.e Naproxen was used which is one of the most potent non-steroid and anti-inflammatory drug for the treatment of various bone related diseases .In our study we have prepared pH sensitive naproxen-pullulan delivery system in which Pullulan acetate was synthesized by treating 2.5 gm of crude pullulan with 25 ml of formamide at 50°C. For the loading of drug 50 mg of Pullulan acetate was dissolved 5 ml of dichloromethane and to it 80 mg of Naproxen was added. The drug loading efficiency of the prepared microparticle was found to be 80%. The microsphere was also showing a pH sensitive swelling behaviour in Phosphate Buffer Saline (PBS) buffer. The release profile of the drug loaded microsphere reveals that pH of the medium was influencing it at in vitro condition. Moreover the released amount of drug from the pullulan based microsphere at pH 7.2 was 75 times more than that at the pH 1.2. Therefore Pullulan acetate loaded with Naproxen is a useful polymerised materials for the development and formulation of pH sensitive drug. *Corresponding author, Mailing address: Dr. Suneetha Vuppu and Mr. Bishwambhar Mishra Instrumental and Food Analysis Lab, 115,Hexagon e-mail: vsuneetha@vit.ac.in ; bishwambharmishra@vit.ac.in Article History:------------------------ Date of Submission: 04-07-2012 Date of Acceptance: 21-08-2012 Conflict of Interest: NIL Source of Support: NONE Full Length Research Paper Covered in Index Copernicus with IC Value 4.68 for 2010 Int. J. Drug Dev. & Res., October-December 2012, 4 (4): 184-191 Covered in Scopus & Embase, Elsevier 184