Sriwidodo et al., Int. J. Res. Pharm. Sci., 2020, 11 (SPL4), 2154-2157 OėĎČĎēĆđ AėęĎĈđĊ IēęĊėēĆęĎĔēĆđ JĔĚėēĆđ Ĕċ RĊĘĊĆėĈč Ďē PčĆėĒĆĈĊĚęĎĈĆđ SĈĎĊēĈĊĘ Published by JK Welfare & Pharmascope Foundation Journal Home Page: www.pharmascope.org/ijrps Physicochemical Characterization of Concentrated Mineral and Magnesium Isolate of Sea Water Pamekasan Madura Sriwidodo *1 , Abd. Kakhar Umar 1 , Ega Megawati 1 , Maria Elvina Tresia Butarbutar 1 , Nasrul Wathoni 1 , Syaϐika Alaydrus 2 1 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor-45363, Indonesia 2 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor-45363, Indonesia Article History: Received on: 17 Sep 2020 Revised on: 17 Oct 2020 Accepted on: 19 Oct 2020 Keywords: Concentrated mineral, Pamekasan Madura, Sea Water, Magnesium Isolates AćĘęėĆĈę Seawater contains many types of minerals that can be used in the health sec- tor as raw materials for medicines and supplements. In Indonesia, one of the biggest mineral salt-producing areas is Pamekasan Madura with a recent record income of 2,768,809.95 tons. The many mineral resources available and the potential development of medicinal raw materials, it is necessary to check the initial physicochemical properties as a source of information for fur- ther research. This study aims to analyze the content, and physicochemical properties of concentrated minerals and magnesium isolates from seawater Pamekasan Madura. After analyzed, it was found that the concentrated min- eral contained as many as 25 types of minerals and has a viscosity of 15 mPa.s, a speciϐic gravity of 1,318 - 1,330 with a Baume value of 35-36, and pH of 6.1. The highest mineral concentrations are Sodium (32948.8012 mg / L), Magne- sium (20685.5644 mg / L), and Calcium (349.7602 mg / L). Mineral concen- trations of seawater Pamekasan Madura were found to be greater than the sur- face waters of Taiwan Yes Mineral. Magnesium isolate has a purity of 10.88%. Based on the result, it can be concluded that seawater Pamekasan Madura is a potential source of raw material for mineral medicines. * Corresponding Author Name: Sriwidodo Phone: +62 22 84288888 Email: sriwidodo@unpad.ac.id ISSN: 0975-7538 DOI: https://doi.org/10.26452/ijrps.v11iSPL4.4436 Production and Hosted by Pharmascope.org © 2020 | All rights reserved. INTRODUCTION Indonesia is a maritime country with 75% of the total territory. The sea area (inland waters, islands and territorial sea) is 3,351 million km 2 , the waters of the Exclusive Economic Zone and the continen- tal shelf are 2,936 million km 2 . The length of the coastline of Indonesia is approximately 99,093 km (Badan Informasi Geospasial, 2017). The total number of villages recorded has a salt-raising busi- ness of 493. It is the smallest number com- pared to other types of businesses located in the seaside area with total salt production in 2015, around 2,768,809.95 tons (Central Bureau of Statis- tics, 2018). Seawater contains many types of miner- als. The mineral content with the highest amount is Sodium, Magnesium, Potassium, Calcium and Boron (Mero, 1965). The mineral content in Indone- sia seawater has a higher level than seawater in Egypt, China, India, Singapore and Uganda (Apriani et al., 2018). Minerals have an important role in maintain- ing human physiological and metabolic conditions. 2154 © International Journal of Research in Pharmaceutical Sciences