Original Manuscript Clinical Case Studies 2023, Vol. 0(0) 1–17 © The Author(s) 2023 Article reuse guidelines: sagepub.com/journals-permissions DOI: 10.1177/15346501231198889 journals.sagepub.com/home/ccs A Transdiagnostic Prevention Support Group for Caregivers of Children With Autism Spectrum Disorder: A Case Example Aileen Kangavary 1,2 , Elizabeth R. Halliday 1 , Jennifer Durocher 1 , and Jill Ehrenreich-May 1 Abstract Caregivers of children with autism spectrum disorder (ASD) experience increased levels of stress, anxiety, and depression compared to caregivers of neurotypical children. The high levels of stress and the prevalence of emotional disorders experienced by caregivers may negatively impact their capacity and confidence to effectively manage their child’s complex emotional and behavioral needs. Given these demands, caregivers of children with ASD require additional support to improve their psychological well-being and parenting self-efficacy. While support programs and treatments for children and adolescents with ASD are abundant, prevention programs that specifically targeted the emotional well-being of caregivers during the COVID-19 pandemic were limited. In this case paper, we describe Coping Options for Parent Empowerment (COPE), a prevention program for parents adapted from the Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Adults, Children, and Adolescents developed during the pandemic. To alleviate the stressors faced by caregivers during the pandemic and beyond, including increased caregiving responsibilities and financial difficulties, Project COPE targeted parent anxiety and depression through four brief, telehealth group sessions provided free of cost for caregivers of school-age children with ASD. In the case example presented, decreases in anxiety and de- pression, and increases in parent self-efficacy were reported after completing this program. Key insights about the intervention’s feasibility and content reported by parents are described. Findings suggest that the intervention removes some treatment access barriers typically seen in caregivers of children with ASD during and following the pandemic and that the program can be modified to increase engagement and acceptability. 1 University of Miami, Miami, FL, USA 2 University of South Florida, Tampa, FL, USA Corresponding Author: Aileen Kangavary, Department of Education, University of South Florida, 4110 USF Apple Dr, Tampa, FL 33620, USA. Email: aileenkangavary@usf.edu