167 ISSN: 2347-7881 PharmaTutor Magazine | Vol. 2, Issue 6 | magazine.pharmatutor.org Research Article Evaluation of Diuretic Activity of Glycyrrhiza Glabra Linn in Experimental Animals Nandu Kayande 1 *, Pankaj Kushwah 2 1 Department of Pharmacology, Nimar Institute of Pharmacy, MP 2 Department of Pharmacognosy, Nimar Institute of Pharmacy, Dhamnod, Dhar, Madhya Pradesh, India *nandu_kayande@rediffmail.com ABSTRACT The purpose of the present study was to evaluate the diuretic activity of glycyrrhiza glabra linn (Mulethi) in experimental animals by following the standard procedure. Randomly selected animals were divided into three groups of six animals each. The root of glycyrrhiza glabra linn was administered orally in the form of Kwatha at a dose of 6.2 ml/kg and 12.3 ml/kg. Parameters like volume of urine, pH of urine and urinary electrolyte concentrations like sodium, potassium and chloride were studied. glycyrrhiza glabra linn Kwatha increased the urine output in a dose-dependent manner. However, it did not affect the urinary electrolyte concentrations. From the present study, it can be concluded that the root of glycyrrhiza glabra linn has diuretic property. Keywords: Glycyrrhiza Glabra, Diuretic, volume of urine, pH of urine and urinary electrolyte INTRODUCTION Glycyrrhiza glabra linn belonging to the family, fabaceae. Glycyrrhiza glabra, also known as licorice and sweetwood, is native to the Mediterranean and certain areas of Asia. Historically, the dried rhizome and root of this plant were employed medicinally by the Egyptian, Chinese, Greek, Indian, and Roman civilizations as an expectorant and carminative. In modern medicine, licorice extracts are often used as a flavoring agent to mask bitter taste in preparations, and as an expectorant in cough and cold preparations. Deglycyrrhizinated licorice (DGL) preparations are useful in treating various types of ulcers, while topical licorice preparations have been used to sooth and heal skin eruptions, such as psoriasis and herpetic lesions. Its traditional uses include treating peptic ulcers, asthma, pharyngitis, malaria, abdominal pain, insomnia, and infections [1] . Decoction of the dried root is taken orally as a diuretic, depurative and emollient [2] . It is also used in the treatment of kidney stones [3] and stomach ache [4] . Licorice has been reported to have antioxidant [5] , antiulcer [6] , hepatoprotective [7] , anti-asthmatic [8] , anti-inflammatory, antiviral, anti-diabetic and anticancer activities. The classical Ayurvedic preparation of this plant called glycyrrhiza glabra linn Kwatha, prepared from the root of this plant, have shown excellent relief in patients of Mootrakruchchhra with symptoms of painful micturition and burning micturition. Hence, the present study was carried out to assess the diuretic activity of glycyrrhiza glabra linn root in form of Kwatha (decoction) in experimental animals and also to provide experimental basis to the clinical findings. How to cite this article: N Kayande, P Kushwah; Evaluation of Diuretic Activity of Glycyrrhiza Glabra Linn in Experimental Animals; PharmaTutor; 2014; 2(6); 167-170