Accepted Manuscript 1,2,4-Trisubstituted imidazolinones with dual carbonic anhydrase and p38 mi- togen-activated protein kinase inhibitory activity Hanan H. Georgey, Fatma M. Manhi, Walaa R. Mahmoud, Nehad A. Mohamed, Emanuela Berrino, Claudiu T. Supuran PII: S0045-2068(18)30968-4 DOI: https://doi.org/10.1016/j.bioorg.2018.09.037 Reference: YBIOO 2534 To appear in: Bioorganic Chemistry Received Date: 1 September 2018 Revised Date: 13 September 2018 Accepted Date: 30 September 2018 Please cite this article as: H.H. Georgey, F.M. Manhi, W.R. Mahmoud, N.A. Mohamed, E. Berrino, C.T. Supuran, 1,2,4-Trisubstituted imidazolinones with dual carbonic anhydrase and p38 mitogen-activated protein kinase inhibitory activity, Bioorganic Chemistry (2018), doi: https://doi.org/10.1016/j.bioorg.2018.09.037 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.