IP Archives of Cytology and Histopathology Research 2022;7(2):94–99 Content available at: https://www.ipinnovative.com/open-access-journals IP Archives of Cytology and Histopathology Research Journal homepage: https://www.achr.co.in/ Original Research Article Study of various laboratory parameters in COVID-19 patients at a tertiary care center Lalit Kumar 1 , Nupur Kaushik 1 , Rajdeep Singh 1 , Harendra Kumar 1, *, Ashish Gautum 2 1 Dept. of Pathology, S.N. Medical College, Agra, Uttar Pradesh, India 2 Dept. of Medicine, S.N. Medical College, Agra, Uttar Pradesh, India ARTICLE INFO Article history: Received 01-02-2022 Accepted 07-04-2022 Available online 29-06-2022 Keywords: SARSCoV2 infection Procalcitonin Ferritin Ddimer Lactate dehydrogenase ABSTRACT Introduction: In China, Wuhan City became the epicentre of unexplained cases of pneumonia in December 2019 and was temporarily labelled as, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). World Health Organization renamed it to coronavirus disease 2019 (COVID-19) in February 2020. In COVID-19 patients hematological profile showed increased total leukocyte count (TLC) and neutrophilic count, while decrease in other hematological parameters. The mild increase in TLC was found in severe disease patients; however significant increase was associated with clinical worsening and poor outcome. Significant elevation of various biochemical and inflammatory markers was noticed among COVID-19 patients Materials and Methods: We conducted a retrospective study on RT-PCR confirmed 239 COVID-19 patients who were hospitalized in various COVID-19 facilities from Sept 2020 to Dec 2020. The laboratory data is used in de-identified form and doesn’t reveal identity of any subjects. Results: A total of 239 cases were examined, out of which 176(73.7%) were male and 63(26.3%) were female (M:F ratio= 2.79:1). We found that 104 cases had Hb level ≥ 12gm/dl. We found that maximum patients (175) had TLC level >11000/cumm, 187 patients had ANC level > 7000/cumm. We found that 160 cases had serum urea of >43mg/dl, 134 case with serum creatinine of >1.4gm/dl.134 cases had ALT level of >40IU/L and 143 cases had AST levels of >42IU/L In this study out of 239 cases 126 cases were found to have increased level of all inflammatory markers levels. Conclusion: We found a significant association of various inflammatory markers with haematological and biochemical parameters in COVID-19 patients. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact: reprint@ipinnovative.com 1. Introduction In China, Wuhan city became the epicentre of unexplained cases of pneumonia in December 2019 and was temporarily labelled as, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by Chinese scientists after identification of a novel coronavirus in January 2020. 1,2 The illness spread rapidly around the country and the world reaching a pandemic level. On 30 January 2020, the WHO declared * Corresponding author. E-mail address: dr_haren@yahoo.co.in (H. Kumar). the outbreak of COVID-19 to be a “public health emergency of international concern”. 3 In COVID 19 patients hematological profile showed increased WBC count and neutrophil count, while decrease in lymphocyte, platelet, eosinophil count, and hemoglobin level. 4 The research data of last few months revealed the slightly increase in levels of ALT, AST, ALP and bilirubin along with significant increase in levels of renal biomarkers such as serum urea; creatinine and markers of glomerular filtration rate in critically ill patients. 2,5–9 https://doi.org/10.18231/j.achr.2022.020 2581-5725/© 2022 Innovative Publication, All rights reserved. 94