S-1 Supporting Information Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus David McGowan,* Florence Herschke,* Frederik Pauwels, Bart Stoops, Stefaan Last, Serge Pieters, Annick Scholliers, Tine Thone, Bertrand Van Schoubroeck, Dorien De Pooter, Wendy Mostmans, Mourad Daoubi Khamlichi, ‡ Werner Embrechts, Eric Arnoult, § Samuël Demin, Gregory Fanning, Jaromir Vlach, † Pierre Raboisson Janssen Infectious Diseases Diagnostics BVBA, Turnhoutseweg 30, 2340 Beerse, Belgium ‡ Villapharma Research S.L., Parque Tecnológico de Fuente Álamo. Ctra. El Estrecho- Lobosillo, Km. 2.5- Av. Azul 30320 Fuente Álamo de Murcia, Murcia, Spain Contents of Supporting Information Contents Page Preparation of intermediates S-2 Biological Assays Molecular Modeling S-11 S-15 1 H and 13 C NMR Spectra S-19