Accepted Article This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/liv.13546 This article is protected by copyright. All rights reserved. DR. FRANCESCO TOVOLI (Orcid ID : 0000-0002-8350-1155) PROF. FABIO PISCAGLIA (Orcid ID : 0000-0001-8264-1845) Article type : Original Articles Editor : Alejandro Forner Oral oxycodone/naloxone for pain control in liver cirrhosis: observational study in patients with symptomatic metastatic hepatocellular carcinoma Francesco Tovoli 1 , Stefania De Lorenzo 2 , Boaz Gedaliahu Samolsky Dekel 3 , Fabio Piscaglia 1 , Francesca Benevento 1 , Giovanni Brandi 2 , Luigi Bolondi 1 Affiliations: 1. Unit of Internal Medicine, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy 2. Unit of Oncology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy 3. Unit of Anesthesiology and Pain Medicine, Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy Corresponding author: Francesco Tovoli Via Massarenti 9, 40138 Bologna, Italy