www.wjpps.com │ Vol 12, Issue 5, 2023. │ ISO 9001:2015 Certified Journal │ 1553 Ali et al. World Journal of Pharmacy and Pharmaceutical Sciences NEW DIGLUCOSIDE AND PHENOLIC GLYCOSIDIC ESTERS FROM THE STEM BARK OF FICUS CARICA L. Showkat R. Mir 1 , Mohammed Ali 1 *, M. Zaffer Ahmad 1 and Shahnaz Sultana 1,2 1 Phytopharmaceuticals Research Laboratory, Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, P.O. Hamdard Nagar, New Delhi – 110062, India. 2 Present address: College of Pharmacy, Jazan University, Jazan, Saudi Arabia. ABSTRACT Ficus carica L. (Moraceae) is a deciduous, laticifer, spreading tree indigenous to Asia Minor, Persia, Syria, Mediterranean region and Indian subcontinent. The bark is antiseptic, bitter, febrifuge, tonic and vermicidal, and a decoction of the bark is taken to treat diabetes, skin diseases and ulcers. Phytochemical investigation of a methanolic extract of its stem bark resulted in the isolation of four new phytoconstituents characterized as 6-methoxy- β-D-glucopyranosyl- (1→4')-O-β-D-glucopyranoside (methoxy diglucoside, 1), n-decanoyl O-β-D-glucopyranosyl-(2ʹ→1ʹʹ)-O-β-D-glucopyranoside (caproyl diglucoside, 2), 3,4-dipalmityl 5-β-D-galactopyranosyl gallic acid (gallic acid galactosidic dipalmitate, 3) and vanillic acid 4-O-β-D- arabinopyranosyl-(2a→1b)-O-β-D-glucopyranosyl-(2b→1c)-O-β-D- glucopyranosyl- (2c→1d)-O-β-D-glucopyranosyl- (2d→1e)-O-β-D- glucopyranosyl- (2e→1f)-O-β-D-glucopyranosyl- (2f→1g)-O-β-D- glucopyranosyl- 4a-O-heptan-6′-one, (vanillin 4-O-heptaglycosidic heptan-6′ -one, 4). The structures of isolated phytoconstituents were established on the basis of analysis of spectral data and chemical means. KEYWORDS: Ficus carica, stem bark, Phenolic glycosides, Isolation, Characterization. INTRODUCTION Ficus carica L. (Family Moraceae), known as anjeer and fig, is indigenous to Asia Minor, Persia, Syria and the Mediterranean region, and widely found in tropical and subtropical WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 7.632 Volume 12, Issue 5, 1553-1566 Research Article ISSN 2278 – 4357 *Corresponding Author Prof. Mohammed Ali Phytopharmaceuticals Research Laboratory, Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, P.O. Hamdard Nagar, New Delhi – 110062, India. Article Received on 13 March 2023, Revised on 03 April 2023, Accepted on 23 April 2023 DOI: 10.20959/wjpps20235-24783