Acta Scientific Pharmaceutical Sciences (ISSN: 2581-5423) Volume 5 Issue 4 April 2021 Solubility Enhancement of Azithromycin by Solid Dispersion Technique Using Mannitol and β-Cyclodextrin Veer Patel 1 *, Rakesh Patel 2 , Hetansh Shah 1 , Shyam Purohit 1 , Mayur Pawar 1 and Abuzar Pathan 1 1 Faculty of Pharmacy, Department of Bachelor of Pharmacy (B. Pharm), Parul Institute of Pharmacy, Parul University, Vadodara, Gujarat, India 2 Faculty of Pharmacy, Department of Pharmaceutics, Parul Institute of Pharmacy, Parul University, Vadodara, Gujarat, India *Corresponding Author: Veer Patel, Bachelor of Pharmacy (B. Pharm), Parul Institute of Pharmacy, Parul University, Vadodara, Gujarat, India. Research Article Received: March 02, 2021 Published: March 20, 2021 © All rights are reserved by Veer Patel., et al. Abstract Background: Azithromycin is a poorly water soluble drug having low solubility. Dissolution is the rate-limiting step in absorption of such drugs. Therefore, solubility of such drugs need to be enhanced in order to have a stable and effective dosage form having greater bioavailability. Solid dispersion technique is one of the effective methods to enhance the solubility of poorly soluble drugs. Aim and Objectives: The present study aimed at enhancing the solubility of biopharmaceutical classification system Class II Drug, i.e. Azithromycin using Mannitol and β-Cyclodextrin as a carrier. Method: Solid dispersions of Azithromycin with Mannitol and β-Cyclodextrin were prepared by Melting, Kneading and Solvent Evap- oration method. The solubility of these prepared dispersions was evaluated. Results: Solubility of prepared dispersions of Azithromycin were reported in µg/mL. The solubility of solid dispersion which was prepared using the Drug: Mannitol mixture in 1:4 ratio was found to be maximum, i.e. reported solubility of 7.8 µg/mL. The solubil- ity of solid dispersion which was prepared using Drug: β-Cyclodextrin mixture in 1:1.5 ratio was found to be maximum, i.e. reported solubility of 9.52 µg/mL. The solubility of those dispersions that were prepared using Melting and Kneading Method were found to be maximum. Conclusion: Drug having less aqueous solubility can have an enhanced rate of dissolution by using solid dispersion technique. Keywords: Azithromycin; Solubility; Solid Dispersion; BCS (Biopharmaceutical Classification System); Absorbance Abbreviations BCS: Biopharmaceutical Classification System; HCL: Hydrochloric Acid. Introduction Azithromycin, a macrolide antibiotic of the azalide subclass, exerts its antibacterial action by binding to the 50s ribosomal subunits of susceptible bacteria and suppressing protein syn- thesis; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring. Azithromycin is a white crystalline powder with a molecular formula of C 38 H 72 N 2 O 12 and a molecular weight of 749.0 gm/mol. Azithromycin is a broad spectrum antimicrobial agent with oral Citation: Veer Patel., et al. “Solubility Enhancement of Azithromycin by Solid Dispersion Technique Using Mannitol and β-Cyclodextrin". Acta Scientific Pharmaceutical Sciences 5.4 (2021): 48-54.