International Journal of Research in Dermatology | October-December 2019 | Vol 5 | Issue 4 Page 861 International Journal of Research in Dermatology Kumar KM et al. Int J Res Dermatol. 2019 Nov;5(4):861-869 http://www.ijord.com Original Research Article Role of different topical modalities in improvement of facial hyperpigmentation and skin rejuvenation Kunwar Manoj Kumar 1 , Amit Kumar Pandey 1 *, Aayushi Mohan 2 , Surya Kant Ojha 1 INTRODUCTION Facial hypermelanosis are a common presentation in most of patients, causing cosmetic disfigurement with considerable psychological impact. With age skin starts to show sign of ageing, especially on face and exposed parts of body. Apart from this, facial skin can lose its complexion and texture due to many other dermatological conditions. Long duration outdoor activities result in tanning, and photo aging. Melasma in another very common hyperpigmentary disorder and its prevalence is high in females due to intrinsic factors. Normal skin color is determined by number of chromophores, the most important of which is melanin. Racial and ethnic differences is in skin color are related to number, size, shape, distribution and degradation of melanin-laden organelles called melanosomes. These are produced by melanocytes and are transferred to keratinocytes. 1 ABSTRACT Background: Facial hypermelanosis is a psychologically stressful condition for modern men and women who are cosmetically more conscious than their ancestors. There are various lightening agent used for several months before effect becomes apparent and are much more effective when pigment is epidermal. these topical agents include hydroquinone, liquorice derivatives niacinamide, glycolic acid, arbutin and deoxyarbutin, ascorbic acid, 4-n-butyl resorcinol, retinoids topical steroids mequinol, kojic acid, azelaic acid, 5% tranexmic acid, glutathione cream etc. Methods: A randomized, controlled study was done. 220 patients were given either treatment will be given depending upon the physician choice after taking well informed consent from the patient. Patients' assessment regarding the degree of improvement of complexion since the beginning of therapy was evaluated. Results: The percentage satisfactory response for different modalities was as follow kojic acid 2% cream- 55.55%, 20% azelaic acid cream- 53.12%, 4-n-butyl resorcinol 0.3% cream- 57.89%, 5% tranexmic acid lotion- 48.83% and glutathione cream- 55.76%. Conclusions: Out 220 patients post inflammatory hyperpigmentation was the most common facial condition. Total 61 patients of PIH were there in the present study including 26 males and 35 females followed by melasma. All The modalities were effective in the treatment of different types- pigmentary conditions. Keywords: Kojic acid, Azelaic acid, 4-n-butyl resorcinol, Tranexamic acid, Glutathione 1 Department of Dermatology, BRD Medical College, Gorakhpur, Uttar Pradesh, India 2 Department of Dermatology, NRS Medical College, Kolkatta, West Bengal, India Received: 09 September 2019 Revised: 17 October 2019 Accepted: 18 October 2019 *Correspondence: Dr. Amit Kumar Pandey, E-mail: amitpandey044@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20194683