International Journal of Research in Dermatology | July-August 2023 | Vol 9 | Issue 4 Page 175 International Journal of Research in Dermatology Pandey AK et al. Int J Res Dermatol. 2023 Jul;9(4):175-181 http://www.ijord.com Original Research Article A comparative study of narrowband-ultraviolet B plus intralesional normal saline versus narrowband-ultraviolet B with platelet rich plasma in treatment of vitiligo Amit K. Pandey 1 , Aayushi Mohan 2 *, Prannav Satyaraj 1 INTRODUCTION Vitiligo is a common acquired idiopathic and often, familial hypomelanosis, which is characterized by pale white macules that enlarges centrifugally over time. Vitiligo alone involved 1-2% of the world’s population. It causes cosmetic problems as well as socio-psychological disaster. 1 Prevalence of vitiligo figures from nearly 1–2% of the world population. 2 In India, the incidence of vitiligo in dermatological outpatient is around 3% to 4%. 3 There are many cases of vitiligo who either fail to respond or only partially respond to medical line of treatment indicating melanocytes are targeted by multiple aggressions leading to marked reduction of pigment cells and eventually to their complete destruction. 4 The various medical therapeutic modalities used for treatment of vitiligo have certain limitations. “Stable vitiligo” is the term carried for such cases where, in addition, the disease is inactive and no new patch has DOI: https://dx.doi.org/10.18203/issn.2455-4529.IntJResDermatol20231824 ABSTRACT Background: Treatment of vitiligo remains a challenge and there is no universal consensus about optimal treatment. Platelet rich plasma contains several growth factors and is being used as an effective treatment of several dermatological disorders. Now it is clear that along with melanocytes, keratinocytes and fibroblasts are also involved in pathogenesis of vitiligo. The aim of this study was to compare the effect of narrowband-ultraviolet B (NB-UVB) with platelet rich plasma versus NB-UVB and intralesional normal saline in treatment of vitiligo. Methods: A prospective observational study was done between March 2016 to August 2017 on patients of vitiligo attending BRD Medical College, Gorakhpur. A total of 80 patients were enrolled with symmetrical lesions. For each patient one side was treated with NB-UVB along with intralesional platelet-rich plasma (PRP) and other side with NB- UVB plus intralesional normal saline was given. Intralesional PRP and intralesional normal saline was given on an interval of every 2 weeks for 4 months and patients were receiving NB-UVB therapy thrice weekly on alternate day. Results: We found that combination of PRP with NB UVB had statistically significant improvement as compared to NB UVB alone with pigmentation detected in 60% patient in combined site versus 20% in NB UVB plus intralesional normal saline. Conclusions: Intradermal PRP injections along with NB-UVB are efficacious, safe, cheap and easy technique in treatment of vitiligo it is more efficacious when compared to NB-UVB therapy. It also shortens the duration of NB- UVB therapy. Keywords: Vitiligo, NB-UVB, Platelet rich plasma, Intralesional saline 1 Department of Dermatology, Autonomous Medical College, Pratapgarh, Uttar Pradesh, India 2 Department of Dermatology, Dr. Janki Prasad Sevashram, Gorakhpur, Uttar Pradesh, India Received: 12 April 2023 Revised: 15 May 2023 Accepted: 02 June 2023 *Correspondence: Dr. Aayushi Mohan, E-mail: mohanaayushi@yahoo.in Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.