1.Introduction Antimicrobial resistance (AMR) represents a far-reaching and substantial danger to public health. The emergence of AMR leads to complications in treating infections, contributing to a rise in mortality rates. The broad occurrence of AMR, along with the excessive utilization of antimicrobial drugs, creates a substantial challenge for the restoration of human and animal populations. Urgent attention is required to devise innovative treatments and therapeutics that can effectively address the emergence and spread of resistant strains. Research indicates that AMR gene development and dissemination are primarily linked to overreliance on health drugs, improper use in veterinary medicine, agricultural practices, and vaccine hesitancy. Thankfully, promising approaches have surfaced to combat resistance effectively. These methods encompass antivirulent therapy, passive immunization, antimicrobial peptides, vaccines, phage therapy, as well as botanical and liposomal nanoparticles. Each of these innovative techniques aims to alleviate the strain on antibacterial drugs, representing cutting- edge approaches in the field. This review article focuses on the importance of employing these advanced therapeutics to combat AMR. To effectively tackle AMR, a comprehensive strategy is essential. This involves harnessing current cutting-edge therapeutics, advancing antimicrobial susceptibility testing and diagnostic techniques, and ensuring prompt clinical responses to contain AMR's spread. Furthermore, there is a need for research to explore new pharmacodynamic properties of antimicrobials and develop methods to maintain host homeostasis after AMR-caused infections. Addressing AMR calls for a multifaceted approach, involving the appropriate use of advanced antimicrobial drugs in conjunction with diverse cutting-edge therapeutics. In summary, AMR represents a pressing global health challenge. However, by employing current state-of-the-art therapeutics, advancing diagnostic and treatment methods, and continuously conducting research, we can aspire to reduce its impact and safeguard the health of both human and animal populations. 2. New antibiotic discovery 2.1. Genome-scale screening technique Genome mining uncovers new antibiotics through biosynthetic gene clusters (BGC). Tools like anti-SMASH and PRIS identify BGCs. Strategies include ribosome engineering, CRISPR-Cas9, and small molecule elicitor use. Examples include lactocillin, halophile, taromycin A, and piperidine A/B (1-4). APTI Women's Forum Newsletter, May - Aug 2023 | 63 Emerging frontier approaches for the treatment of antimicrobial resistance Saba Khan, Jaya Agnihotri* Department of Pharmaceutics, MES H.K College of Pharmacy, Jogeshwari (W), Mumbai, Maharashtra-400083, India jaya.agnihotri@hkcp.edu.in