Accepted Manuscript Natural isoflavone biochanin A as a template for the design of new and potent 3- phenylquinolone efflux inhibitors against Mycobacterium avium Rolando Cannalire, Diana Machado, Tommaso Felicetti, Sofia Santos Costa, Serena Massari, Giuseppe Manfroni, Maria Letizia Barreca, Oriana Tabarrini, Isabel Couto, Miguel Viveiros, Stefano Sabatini, Violetta Cecchetti PII: S0223-5234(17)30696-7 DOI: 10.1016/j.ejmech.2017.09.014 Reference: EJMECH 9729 To appear in: European Journal of Medicinal Chemistry Received Date: 29 June 2017 Revised Date: 6 September 2017 Accepted Date: 10 September 2017 Please cite this article as: R. Cannalire, D. Machado, T. Felicetti, S.S. Costa, S. Massari, G. Manfroni, M.L. Barreca, O. Tabarrini, I. Couto, M. Viveiros, S. Sabatini, V. Cecchetti, Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium, European Journal of Medicinal Chemistry (2017), doi: 10.1016/ j.ejmech.2017.09.014. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.