432 1788 Board #321 June 1 3:30 PM - 5:00 PM Effect Of Panax Notoginseng (Chinese Ginseng) And Cycling Exercise On Il-6 And Cortisol In Untrained Non-diabetic Men W.Y. Jamie Lau 1 , Michael T.c. Liang, FACSM 1 , Bülent Sökmen 2 , Thomas W. Spalding 1 , Lorena Quezada 1 , William J. Chuang 3 . 1 California State Polytechnic University Pomona, Pomona, CA. 2 Sonoma State University, Rohnert Park, CA. 3 The Chuang Foundation, Hayward, CA. Email: Jamie.lau@hotmail.com (No relationships reported) PURPOSE: The purpose of this experiment was to examine the effect of a 3-g dose of Panax notoginseng (PNG) supplementation for 3 days with and without a single bout of 30-min exercise on interleukin-6 (IL-6) and cortisol concentrations in untrained nondiabetic men. METHODS: The subjects, ages 20-35 yr, were randomly assigned to: 1) ginseng plus exercise (G+E, n = 8), 2) ginseng only (G, n = 8), 3) control plus exercise (C+E, n = 10) and 4) control (C, n = 10) groups. The ginseng groups and the placebo-control groups were given a daily 3-g dose of PNG and cornstarch- placebo supplement for 3 days, respectively. All participants took the last 3-g dose of PNG or placebo on day 3 in the morning without breakfast. On the same day, while the G and C groups rested for 30 min, the G+E and C+E groups performed one bout of 30 min cycling exercise at 60% VO2max followed by the administration of a 75-g oral glucose tolerance test (OGTT). Venous blood samples were taken 30 min before the exercise (or the rest period) and at 30 min post-OGTT for the determination of plasma IL-6 and cortisol concentrations. RESULTS: The 3 g . d -1 PNG supplementation taken for 3 days did not alter IL-6 (mean ± SE: 1.27 ± 0.36 vs. 1.94 ± 0.32 and 1.62 ± 0.34 pg . ml -1 , all p>0.05) or cortisol (364.9 ± 5.1 vs. 368.4 ± 4.5 and 363.9 ± 4.8 nmol . L -1 , all p>0.05) concentrations, compared to C+E and C groups. Also, PNG plus exercise likewise did not alter IL-6 or cortisol levels compared to G and C groups. CONCLUSIONS: There was a null effect of a 3-g dose of PNG supplementation on IL-6 and cortisol, after an acute 30-min cycling exercise at 60% VO2max and the 75-g oral glucose tolerance test.. 1789 Board #322 June 1 3:30 PM - 5:00 PM Effects of Chicken Essence with Ginseng Extracts Supplementation on Physiological Fatigue and Metabolic Response after Exhaustive Exercise Ting-Ting Chen 1 , Li-Yen Tsao 2 , Sharon Hsu, FACSM 3 , Mei-Chich Hsu 1 . 1 National Taiwan Sport University, Taoyuan, Taiwan. 2 National Taipei College of Business, Taipei, Taiwan. 3 California State University, Northridge, CA. (No relationships reported) Chicken essence and ginseng both are commonly used as a traditional remedy, particularly in Chinese communities in Southeast Asia. Chicken essence has been reported to enhance recovery from fatigue, increases metabolic rate, and other effects. Ginseng also are purported to reduce fatigue and improve physical stamina. However, the effects of the combined chicken essence and ginseng extract on post-exercise physiological fatigue and metabolic response have yet to be elucidated.PURPOSE: This study was to investigate the effects of chicken essence with ginseng extracts (CEG) supplementation on acute metabolic responses during recovery after a single bout of exhaustive exercise. METHODS: Fourteen healthy males were assigned to drink with either CEG or placebo (PL) on two sessions separated by 2 weeks. After 8 hr fasting, they run on a treadmill until exhaustive. Blood samples were collected before exercise, and 0, 5, 10, 15, 30, 60 and 120 min after exercise, respectively. The next day, subjects run on a treadmill at an estimated speed corresponding to their 75% VO2max which was used to evaluate the performance between two groups. RESULTS: No significant differences in the levels of blood glucose, lactate, creatine kinase, insulin and free fatty acid between two groups were observed at any of the time points. However, the levels of ammonia was significantly lower in the CEG group as compared to those in the PL group at the 60 and 120-min recovery period (12.4±6.7 μmol/L vs. 25.5±14.0 μmol/L, 8.6±6.7 μmol/L vs. 17.7±14.3 μmol/L, p<.05). The eliminate rate of ammonia at 60 and 120-min recovery period were significantly higher in the CEG group. (88.3±6.0 % vs. 74.5±12.5 %, 92.0±7.0 % vs. 82.5±13.4 %, p<.05). Additionally, the performance time of 75% VO2max running were significantly longer in the CEG group, as compared to that in the PL group (1625.5 ± 552.8 sec vs. 1451.5 ± 528.9 sec, p<.05). CONCLUSION: Supplementation with chicken essence with ginseng extracts could enhance physiological recovery after an exhaustive exercise and prolong the 75% VO2max running exercise duration. 1790 Board #323 June 1 3:30 PM - 5:00 PM Effects Of Panax Ginseng Supplementation On Muscle Damage And Inflammation After Treadmill Running In Humans Hyun Lyung Jung 1 , Ho Youl Kang 1 , Ying Chang 1 , Tae Un Kim 2 . 1 Kyungpook National University, Daegu, Korea, Republic of. 2 Busan National University, Busan, Korea, Republic of. Email: woman-jhl@hanmail.net (No relationships reported) PURPOSE: This study was to determine whether Panax ginseng extract intake influenced exercise-induced muscle damage and inflammation responses. METHODS: Eighteen male college students were randomly assigned to either an RG intake group (RG, n=9) or a placebo group (P, n=9). All subjects performed a high-intensity uphill treadmill running task (two rounds of 45 min at 10 km/h speed with a 15 degree uphill slope separated by five min of rest). The RG group ingested 20 grams/day of Korean red ginseng extract (mixed with 200 ml of water) three times/day for seven days prior to performing the uphill treadmill exercise test and for four days after the treadmill test, while the P group ingested 200 ml of water containing Agastachis Herba on the same schedule. Plasma creatin kinase activity (CK) and interlukin-6 (IL-6) levels were measured pre-exercise and 24, 48, 72, and 96 h post-exercise; the IL-6 level was also measured 1 and 2 h post-exercise. To evaluate insulin sensitivity, the oral glucose tolerance test (OGTT) was performed 24 h post-exercise. RESULTS: Plasma CK level RG (223.5 ± 8.5 IU/L) had a lower CK 72 h after exercise compared with that of the P (263 ± 10.5 IU/L) ( p <0.05), and IL-6 level was significantly decreased in RG during the 2 h (P; 0.26 ± 0.03, RG; 0.22 ± 0.02 pg/ml, p <0.05) and 3 h (P; 0.28 ± 0.05, RG; 0.21 ± 0.03 pg/ml, p <0.05) recovery period compared to that of P. Plasma glucose and insulin responses in RG (5.6 ± 0.4 mmol/L, 50.8 ± 6.7 pmol/L, respectively) were significantly reduced compared to those of P (7.0 ± 0.2 mmol/L, 78.8 ± 14.0 pmol/L, respectively) (p < 0.05). CONCLUSIONS: The results of this study suggest that RG supplementation could reduce exercise-induced muscle damage and inflammatory responses, resulting in improvements in insulin sensitivity. Copyright © 2011 by the American College of Sports Medicine. Unauthorized reproduction of this article is prohibited.