____________________________________________________________________________________________ *Corresponding author: Email: nora@medic.ukm.my; Annual Research & Review in Biology 4(24): 4075-4083, 2014 SCIENCEDOMAIN international www.sciencedomain.org Anti-Bacterial Activity of Endophytic Streptomyces sp. towards Acinetobacter baumannii Noraziah Mohamad Zin 1* , Norhidayah Badya 2 , Aishah Ismail 1 , Alfizah Hanafiah 3 and Jalifah Latip 4 1 Programme of Biomedical Science, School of Diagnostic Science and Applied Health, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia. 2 Faculty of Medicine and Health Sciences, Universiti Sultan Zainal Abidin, 20400 Kuala Terengganu, Terengganu, Malaysia. 3 Department of Medical Microbiology and Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000 Kuala Lumpur, Malaysia. 4 School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia. Authors’ contributions This work was carried out in collaboration between all authors. Author NB done all the lab works, managed the literature searches and wrote the first draft of the manuscript, with fully supervised by author NMZ in all its aspects. Author AI helped during the collecting of samples. Author AH prepared A. baumannii isolates while author JL contributed in TLC part. Authors NMZ, AH and JL managed in the analyses of the study. All authors read and approved the final manuscript. Received 27 th February 2014 Accepted 23 rd May 2014 Published 27 th July 2014 ABSTRACT Aims: To screen fifty-six endophytic streptomyces isolates for anti-bacterial activity on two clinical strains of Acinetobacter baumannii (carbapenem sensitive and resistant). Place and Duration of Study: Universiti Kebangsaan Malaysia; between May 2011 and February 2012. Methods: In this study, 56 isolates of endophytic Streptomyces sp. and their extracts were screened for anti-bacterial activity against A. baumannii. The compound’s profile was obtained for determination of active metabolites Original Research Article