difficult to distinguish between a SLE flare and CMV active infection, making the diagnose challenging. It has also been described in the literature as an exacerbating SLE factor. We report the case of an Asian, 27-year-old woman, with a recent SLE diagnosis that was admitted with a SLE flare while developing a CMV encephalitis. She was previously admitted due to a nephrotic syndrome. Immunological studies revealed an ANA title of 1:640 and a positive anti dsDNA Ab with diminished C3 and C4 levels, nephrotic range proteinuria and a diagnose of SLE was made. Renal biopsy revealed class IV lupus nephritis. She started high dose intravenous methylprednisolone (3 pulses of 500mg) and mycophenolate mofetil (MMF) at a dose of 2g per day. She was discharged taking 60 mg of oral prednisolone and the same dose of MMF. Two weeks after being discharged, she was readmitted due to worsening anaemia (Hb 6.8 g/dL), thrombocytopenia (Pl 27 000/mL) and deteriorating renal function with a sCr of 5.5 mg/dL with de novo haematuria. It was admitted a severe SLE flare and she was given another 3 pulses of 500mg I.V methylprednisolone and cyclophosphamide (CYC) was started (1 pulse of 500mg I.V). At the same time, she started to complain of myalgias and malaise, generalized hypotonia, developed fever, leukopenia with neutropenia and seizures. Serum CMV viremia was 71 000 copies and CMV polymerase chain reaction was positive in cerebrospinal fluid. She was started on I.V Ganciclovir, CYC was suspended and clinical improvement was observed. CONCLUSION: Studies about the risk of different treatment drugs and other risk factors on the development of CMV disease in SLE are lacking. These studies will be useful for establishing guidelines on the institution of prophylaxis or pre-emptive treatment of CMV infection in SLE patients. Protocols for screening and prevention in this population should be implemented to account for this emerging problem. Given the rising prevalence of CMV infection in the past few years, the authors recommend that patients recently diagnosed with SLE while taking high doses of corticosteroids, which appears to be a risk factor for CMV reactivation, should be routinely tested for CMV viremia. There should be a low threshold for suspicion, hence treatment should be started as soon as possible given the high morbidity and mortality in severe cases. MO226 A NEW DIAGNOSTIC TOOL FOR CKD PATIENTS: CONTRAST- ENHANCED ULTRASONOGRAPHY. A SINGLE CENTER EXPERIENCE Mirela Liana Gliga 1,2 , Cristian Chirila 3 , Paula Chirila 4 , Adriana Gomotarceanu 5 , Imola Torok 6 , Mihail Gheorghe Gliga 7 1 University of Medicine, Pharmacy, Science and Technology “George Emil Palade”, Internal Medicine, T^ argu Mures , , Romania, 2 Diaverum Dialysis Center Tirgu Mures, 3 University of Medicine and Pharmacy Science and Technology “George Emil Palade” of T^ argu Mures ¸, Nephrology, 4 Mures University County Hospital, 5 TOPMED Medical Center, Tg Mures, Romania, 6 University of Medicine, Pharmacy, Science and Technology “George Emil Palade” Tg Mures, Romania, Republic Of North Macedonia and 7 University of Medicine, Pharmacy, Science and Technology “George Emil Palade” Tg Mures, Romania BACKGROUND AND AIMS: Contrast-enhanced ultrasonography (CEUS) is a minimally invasive diagnostic tool available for diagnosing microvascular disturbances in tumors and many vascular pathologies. Unlike other radiological contrast agents, it is completely harmless for CKD patients and therefore it is used for the safe diagnosis of many diffuse or focal pathologies. METHOD: We used CEUS examination in 50 CKD patients for the following pathologies: 10 atypical cysts, 15 liver focal lesions, 2 splenic focal lesions, 3 renal infarcts, 12 kidney focal lesions and 8 other organ involvements. Examination was made using a VOLUSON E8 machine (GE Medical System Kreztechnik GmbH Tiefenbach 15, Austria) with a 3.5 MHz convex array abdominal transducer. 2.4 ml of microbubble contrast-agent was administered intravenously and recording of the results were made for 3-5 minutes after injection. RESULTS: Depending on the organ vascular characteristics, contrast enhancement and/or wash-out were suggestive for the final diagnosis. In liver lesions there are three phases and in kidneys, spleen, gallbladder, adenopathies there are two vascular phases. We obtained a very good positive predictive value and sensitivity in detecting malignant lesions. CONCLUSION: According to The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound they are used both for hepatic and Non-Hepatic Applications. Being non-invasive and non-irradiating it could be the main diagnostic examination in CKD population in the future. MO226 Figure: No enhancement in a suspected gallbladder tumor in a dialyzed patient: surgery was avoided MO227 RELATIONSHIP BETWEEN KIDNEY DAMAGE AND COGNITIVE FUNCTIONS IN PATIENTS WITH GLOMERULOPATHIES Gianmarco Borriello 1 , Davide Viggiano 2 , Giovambattista Capasso 3 1 university of Campania ‘Luigi Vanvitelli’, department of translational medicine, naples, , 2 university of Campania ‘Luigi Vanvitelli’ - Biogem, Ariano Irpino, department of trans- lational medicine, naples, and 3 university of Campania ‘Luigi Vanvitelli’ - Biogem, Ariano Irpino, department of translational medicine, naples, Italy BACKGROUND AND AIMS: Mild Cognitive Impairment (MCI) has been found to be highly prevalent amongst patients with Chronic Kidney Disease (CKD). In this cohort, the prevalence of MCI was estimated to be between 30% and 63%. Mild cognitive impairment is an intermediate state between normal aging and dementia. An individual suffering from MCI has difficulty in remembering, sustaining attention, or decision making which can negatively affect their daily lives. The aim of this study was to verify the role of different glomerular diseases diagnosed by kidney biopsy on the MCI through a retrospective study. METHOD: We recruited 45 patients with bioptic diagnosis of the following glomerular diseases: Focal Segmental Glomerulo Sclerosis (FSGS), minimal change disease (MCD), membranous glomerular disease (MG), IgA nephropathy. The renal function was analyzed using clinical variables, while Cognitive functions using the MoCA test. Patients were divided into two groups based on 24h proteinuria. RESULTS: The MoCA score was directly correlated to the uric acid levels (R=0.13; p=0.03). The MoCa score in the group with higher proteinuria levels was significantly lower than those of the group with lower proteinuria levels (p = 0.03). Finally, the MoCA score in subjects with FSGS or MCD is significantly higher compared the other groups (p<0.05). CONCLUSION: Our data suggest that serum uric acid and proteinuria in glomerular diseases influence cognitive functions. Interestingly, uric acid plays a neuroprotective role, as low levels of uric acid reduce the MoCA score. This result agrees with previous observations of a protective role of uric acid on dopamine neurons. Conversely, the extent proteinuria seems to negatively affect cognitive functions, suggesting a role of the endothelial dysfunction. Finally, glomerulopathies with a lower degree of inflammation (FSGS, MCD) have minor impact on cognitive functions. MO228 NATIVE KIDNEY BIOPSIES: DIAGNOCTIC VALUE AND COMPLICATIONS Vadim Stepanov 1 , Elena Prokopenko 1,2 , Aleksei Zulkarnaev 1 , Olga Vetchinnikova 1 , Andrey Yankovoy 1 1 M.F. Vladimirsky Moscow Regional Research Clinical Institute, Kidney Transplantaion Department, Moscow, Russia and 2 Moscow Regional Research Institute of Obstetrics and Gynecology, Outpatient Department, Moscow, Russia BACKGROUND AND AIMS: Percutaneous renal biopsy is essential tool in nephrology but it is invasive procedure that can lead to complications, including gross hematuria, clinical significant haematoma and infection. The aim of the study was to determine the nature and incidence of PRB complications and the impact of biopsy results on treatment strategy. METHOD: 82 patients (male – 42, female – 40) with a median age of 43.5 (Q1; Q3 – 34;71) years, BMI 26.4 (22.9; 30.6) were included in retrospective study of all native kidney biopsies performed at our institute from January 1, 2016 to December 31, 2019. An informed consent was mandatory in all patients. The indications for biopsies were Abstracts Nephrology Dialysis Transplantation i192 | Abstracts Downloaded from https://academic.oup.com/ndt/article/36/Supplement_1/gfab092.00105/6289107 by guest on 29 April 2023