Formulation and Evaluation of Phytosome Drug Delivery System of Boswellia Serrata Extract 94 Int J Res Med. 2015; 4(2);94-99 e ISSN:2320-2742 p ISSN: 2320-2734 Formulation and Evaluation of Phytosome Drug Delivery System of Boswellia Serrata Extract Asit R Sahu 1* , Sunil B Bothara 2 1 C.U.Shah College of Pharmacy & Research, Surendranagar, Gujarat, India 2 Shri Bhagwan College of Pharmacy, Aurangabad, Maharashtra, India INTRODUCTION Throughout human history people have relied on natural products and plants in particular, to promote and maintain good health and to fight sickness, pain and disease. But due to grater awareness to traditional knowledge of these medicinal plants, the allopathic medicines in many ways are replaced by the herbal traditional drugs, this has been evidenced by an increase in no of physicians and public health specialists throughout the world, taking a second look at an alternative generally a traditionally plant based drugs in particular .1,2,3 Now a day, throughout the world search is going on the environmentally safe, non toxic and economically viable plant based products for remedy of various diseases. The currently observed rapid increase in consumption of herbal remedies worldwide has been stimulated by several factors. 4-6 Medicinal plants continue to the *Corresponding Author: Asit Ranjan Sahu Department of Pharmaceutics C. U. Shah College of Pharmacy & Research, Surendranagar, Gujarat Email: asitrsahu@gmail.com Mobile no: +91- 9377489076 quality of life only through prompt and play a central role in the healthcare system of large proportions of the world’s population . The formulation of plant extracts in to dosage form is complex operations which can not be regarded only as a problem of pharmaceutical technology. The researches are going on formulation on plant extract based product and develop the exiting products which absorption is poor, rapid metabolism and rapid systemic elimination; numerous approaches are to be implemented to overcome the problems. 7,8 Most of the biologically active constituents of plant are water soluble molecule. However, water soluble phytoconstituent are poorly absorbed due to their large molecular size which cannot be absorbed by passive diffusion; or due to lower lipid solubility. phytosome are the molecule which can cross lipid rich biomembrane more than normal liposome. 9 Boswellic acid readily penetrates through the hydrophobic stratum corneum while the lower epidermal and dermal layers are hydrophilic in nature, which limits its solubility and transfer of the drug from stratum corneum 10,11 .The present ORIGINAL ARTICLE ABSTRACT BACKGROUND: Boswellic acid is a Phytoconstituent obtained from Shallaki (Boswellia Serrata). Oral use of this drug has some limitations like Low bioavailability, High first pass Metabolism. Conventional treatment include tablet, Capsule; Available in market, have high dose Quantity and Frequency. The aim of the present investigation was to formulate boswellic acid loaded Phytosome for improved delivery. Phytosomal formulations were developed using different concentration of Cholesterol (1-3%) and ethanol (20-40%) then optimized and characterized. Particle size, entrapment efficiency and vesicular shape were determined by Malvern Zetasizer, Ultracentrifugation and Scanning Electron Microscopy, respectively. Particle size varied from 179 to 514.8 nm depending on the concentrations of Cholesterol and ethanol. Entrapment efficiencies were exhibited of 39.8 ± 3.7% to 74.2 ± 4.3 %, where it increased with concentration of cholesterol and ethanol increased. Photomicrographs revealed that optimized Phytosomes were spherical in shape and uniform in size. Based on minimum particle size and maximum entrapment efficiency E6 (2% of Cholesterol concentration and 40% of ethanol concentration) was selected as optimization Phytosomal formulation. Key Words: Boswellic acid, Optimization, Characterization, Phytosome