Research Article Antihyperglycemic, Vasodilator, and Diuretic Activities of Microencapsulated Bioactive Product from Moringa stenopetala Leaves Extract DebebeWorkuDadi , 1 ShimelisAdmassuEmire, 2 AsfawDebellaHagos, 3 FrehiwotTeka, 3 Samuel Woldekidan, 3 Abiy Abebe, 3 and Meron Sileshi 3 1 Department of Food Engineering and Postharvest Technology, Institute of Technology, Ambo University, P.O. Box 19, Ambo, Ethiopia 2 School of Chemical and Bioengineering, Institute of Technology, Addis Ababa University, P.O. Box 385, Addis Ababa, Ethiopia 3 Traditional and Modern Medicine Research Directorate, Ethiopia Public Health Institute, P.O. Box 1242, Addis Ababa, Ethiopia Correspondence should be addressed to Debebe Worku Dadi; debeworku2010@gmail.com Received 25 June 2020; Revised 29 July 2020; Accepted 5 August 2020; Published 14 August 2020 Academic Editor: quancai sun Copyright © 2020 Debebe Worku Dadi et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Moringa stenopetala has nutritional and medicinal values, which is widely used by the local communities. e study aimed to evaluate the antihyperglycemic, vasodilator, and diuretic activities of the microencapsulated bioactive product from M. stenopetala leaves extract. Microencapsulation of the extract was done by spray drying technique using maltodextrin and pectin as coating materials with the core: coating ratio of 1 : 6. en, the antihyperglycemic, diuretic, and vasodilator activities were evaluated after the product was administered to experimental animals at different doses and compared with the control groups. ere were no observed physical, behavioral, and physiological changes on the mice during the acute toxicity test. e results also indicated no toxicity signs and death occurrence in the experimental animals up to 5000 mg/kg administered dose. erefore, microencapsulated M. stenopetala leaves extract does not produce adverse effects in experimental mice. e study also showed that the microencapsulated bioactive product exhibited significant antihyperglycemic, vasodilator, and diuretic activities as the doses increase. erefore, the study showed that microencapsulated bioactive product has significant medicinal values. Further detailed studies are recommended on chronic toxicity tests and to understand the possible mechanism of actions on the antihyperglycemic, vasodilator, and diuretic activities of the microencapsulated product. 1. Introduction Moringa stenopetala plant has biologically active compounds that have beneficial medicinal attributes in addition to food sources and feed. Traditional treatment using different plant extracts is undertaken for many diseases and health disor- ders, in particular, in the developing countries [1]. is is due to the presence of various pharmacological active compounds in the plants. About thirty percent of the marketed drugs contain compounds derived from the plants [2]. Although there are many modern antihypertensive medicines, many peoples prefer to use traditional medicines [3]. M. stenopetala is a plant that has medicinal and nu- tritional importance for the community and reported to have antihypertensive effects [4] and antidiabetic activity [5,6]. Similarly, moringa extract also showed hepato- and kidney protective effects due to its protective action against lipid peroxidation and reactive oxygen species [7]. Fur- thermore, the toxicity and the medicinal values of the M. stenopetala leaves extract have been evaluated using experiments in animal models. e toxicity test of the extract was declared as it does not show toxic signs [2,8]. Phenolic and flavonoid compounds are the major constituents reported from aqueous and alcoholic extracts of Hindawi Journal of Food Quality Volume 2020, Article ID 8882042, 8 pages https://doi.org/10.1155/2020/8882042